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李雅,郭志华,郭慧芳,孙涛,唐云.心痛泰对冠心病大鼠肾素-血管紧张素-醛固酮系统及血管重塑的调控作用[J].湖南中医药大学学报,2017,37(9):943-946[点击复制] |
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| 心痛泰对冠心病大鼠肾素-血管紧张素-醛固酮系统及血管重塑的调控作用 |
| 李雅,郭志华,郭慧芳,孙涛,唐云 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第二附属医院, 湖南 长沙 410005;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 从肾素-血管紧张素-醛固酮系统切入，探讨心痛泰对冠心病血管重塑的调控作用。方法 将95只SD大鼠随机抽取17只为正常组，其余78只采用喂饲高脂饲料并腹腔注射垂体后叶素的方法制备冠心病大鼠模型。将造模成功的大鼠随机分为模型组，心痛泰低、中、高剂量组和卡托普利组。各组分别予相应的药物灌胃，正常组和模型组以同等体积的蒸馏水灌胃，每日1次，连续28 d。采用HE染色观察大鼠冠状动脉病理变化，ELISA法检测大鼠血浆肾素（PRA）、血管紧张素Ⅱ（AngⅡ）、醛固酮（ALD）的含量。结果 治疗4周后，与冠心病模型组比较，心痛泰低、中、高剂量组和卡托普利组心脏指数、左心室质量指数、右心室质量指数降低，冠状动脉管壁变薄，管壁厚度/管腔直径、管壁面积/管腔面积降低，血浆PRA、AngⅡ、ALD水平下降（P<0.05）。心痛泰中、高剂量组和卡托普利组各项指标组间比较，差异无统计学意义（P>0.05）。结论 心痛泰可调节肾素-血管紧张素-醛固酮系统，延缓甚至逆转心血管重构，从而改善冠心病大鼠心肌供血和心功能，且心痛泰中、高剂量组疗效优于低剂量组。 |
| 关键词: 心痛泰 冠心病 心血管重构 肾素-血管紧张素-醛固酮系统 |
| DOI：10.3969/j.issn.1674-070X.2017.09.006 |
| 投稿时间：2016-11-29 |
| 基金项目:湖南省教育厅科学研究项目（16A158）。 |
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| Effect of Xintongtai on Renin-Angiotensin-Aldosterone System and Cardiovascular Remodeling in Rats with Coronary Heart Disease |
| LI Ya,GUO Zhihua,GUO Huifang,SUN Tao,TANG Yun |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the effects of Xintongtai on cardiovascular remodeling in rats with coronary heart disease and illustrate the therapeutic mechanisms from renin-angiotensin-aldosterone system (RAAS). Methods 17 rats as the normal group were randomly selected from 95 SD rats, and the rest, 78 rats were used for coronary heart disease rat models which were established by high fat diets and intraperitoneal injection of Pituitrin. Then the successful model rats were randomly divided into five groups: the model group, low, middle, high dosages of Xintongtai groups and Catopril group. Rats in medication groups were given drug once daily for 28 d, and the normal group and model group were supplied equally volume of distilled water. The pathological changes of rats were measured by HE staining method. The contents of plasma renin activity (PRA), angiotensin (Ang II), aldosterone (ALD) in rats were determined. Results After treatment for 4 weeks, the cardiac index, left ventricular mass index and right ventricular mass index in the medication groups were lower than those in the model group; the walls of the coronary arteries in medication groups were thinner than the model group, and the wall thickness/lumen diameter, wall area/lumen area of the coronary arteries reduced; the levels of PRA, AngⅡ, ALD reduced (all P<0.05). The all above mentioned indicators in middle-dose, high-dose of Xintongtai groups and Catopril group were not statistically different (P>0.05). Conclusion Xintongtai could adjust renin-angiotensin-aldosterone system and display or reverse the cardiovascular remodeling, which improve myocardial blood flow and cardiac function of the rats with coronary heart disease. The effect of middle and high dose of Xintongtai groups is better than the low dose group. |
| Key words: Xintongtai coronary heart disease cardiovascular remodeling renin-angiotensin-aldosterone system |
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