| 引用本文: |
温柔,席建元,谢汶芳,李小鹏,祁林,陈偶英.银屑平丸对寻常型银屑病患者皮损中STAT3和P-STAT3表达的影响[J].湖南中医药大学学报,2016,36(3):64-66[点击复制] |
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| 银屑平丸对寻常型银屑病患者皮损中STAT3和P-STAT3表达的影响 |
| 温柔,席建元,谢汶芳,李小鹏,祁林,陈偶英 |
| (湖南省浏阳市人民医院, 湖南 浏阳 410300;湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410128) |
| 摘要: |
| 目的 通过观察银屑平丸对寻常型银屑病患者皮损中STAT3（信号转导与转录活化因子3）和P-STAT3（磷酸化信号转导与转录活化因子3）表达的影响，探讨银屑病的发病机制及银屑平丸治疗寻常型银屑病的作用靶点。方法 21例寻常型银屑病患者予口服银屑平丸治疗，疗程8周。用免疫组化法检测其治疗前后皮损STAT3、P-STAT3的表达，并与20例整形切除术后的正常皮肤相比较。结果 银屑平丸治疗组治疗前皮损STAT3、P-STAT3的平均灰度值与正常组相比，其表达明显升高（P<0.01）；治疗后皮损STAT3、P-STAT3的平均灰度值较治疗前表达明显下降（P<0.05）。治疗组治疗前后STAT3、P-STAT3的表达呈正相关（P<0.05）。结论 在寻常型银屑病中存在STAT3、P-STAT3的高表达，证实寻常型银屑病的发生、发展与两者相关。银屑平丸通过降低皮损中STAT3、P-STAT3的表达水平，调节银屑病中角质形成细胞的增殖和细胞凋亡，改善银屑病对机体的损伤。 |
| 关键词: 寻常型银屑病 银屑平丸 STAT3 P-STAT3 生地黄 丹皮 白花蛇舌草 |
| DOI：10.3969/j.issn.1674-070X.2016.03.019 |
| 投稿时间：2015-09-25 |
| 基金项目:湖南省科技厅科研项目（2013FJ6077）。 |
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| Effects of Yinxieping Pills on STAT3 and P-STAT3 Expression in Patients with Psoriasis Vulgaris Lesions |
| WEN Rou,XI Jianyuan,XIE Wenfang,LI Xiaopeng,QI Lin,CHEN Ouying |
| (Liuyang People's Hospital, Liuyang, Hunan 410300, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To investigate the psoriasis pathogenesis and action target in the treatment of vulgaris psoriasis by observing Yinxieping pills on the expression of STAT3 and P-STAT3 in patients with psoriasis vulgaris lesions. Methods 21 patients with psoriasis vulgaris were given Yinxieping pills for oral administration, the course for 8 weeks. The expression of STAT3 and P-STAT3 before and after treatment were detected by immunohistochemical method, which was also comapared with the normal skin of 20 cases with plastic surgery and resection. Results Compared with normal group, the expression of STAT3 and P-STAT3 in patients with psoriasis vulgaris was significantly higher than that in normal group (P<0.001), and the expression of STAT3 and P-STAT3 after treatment was significantly decreased (P<0.05). The expression of P-STAT3 and STAT3 was positively correlated (P<0.05). Conclusion The abnormal expression of P-STAT3 and STAT3 in psoriasis vulgaris is higher, which is related to the occurrence and development of psoriasis vulgaris. Yinxieping pills can improve psoriasis on the body damage by reducing the expression of STAT3 and P-STAT3 in the lesions and regulating keratinocytes in psoriasis formation of cell proliferation and apoptosis. |
| Key words: psoriasis vulgaris Yinxieping pills STAT3 P-STAT3 fresh rehmannia cortex moutan oldenlandia |
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