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骆杨平,唐铭翔,王鹏,闫秋林.益心舒胶囊联合美托洛尔缓释片治疗冠心病室性早搏的临床观察[J].湖南中医药大学学报,2016,36(3):60-63[点击复制] |
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| 益心舒胶囊联合美托洛尔缓释片治疗冠心病室性早搏的临床观察 |
| 骆杨平,唐铭翔,王鹏,闫秋林 |
| (湖南省人民医院, 湖南 长沙 410002;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察益心舒胶囊联合美托洛尔缓释片治疗冠心病室性早搏的临床疗效。方法 将100例冠心病伴室性早搏患者随机分为观察组（益心舒胶囊联合美托洛尔缓释片）与对照组（单用美托洛尔缓释片），疗程均为4周。观察用药前后主要临床症状、24 h动态心电图的变化、QT离散度（QTd）变化。结果 在治疗室性早搏疗效方面，两组室性早博次数均减少（P<0.01），且观察组低于对照组（P<0.05），两组总有效率分别为75.0%、57.1%，两组比较差异有统计学意义（P<0.05）；在改善临床症状上，观察组总有效率为62.5%，对照组为55.1%，两组比较差异有统计学意义（P<0.05）；在中医症候疗效改善方面，两组患者中医证侯改善疗效的比较差异有统计学意义（P<0.05），观察组证候疗效优于对照组；与对照组相比，观察组QTd、校正QTd明显下降（P<0.01）。结论 益心舒胶囊联合美托洛尔治疗冠心病室性早搏的疗效明显；可以降低QT离散度，抑制恶性心律失常的发生。 |
| 关键词: 冠心病 室性早搏 益心舒胶囊 美托洛尔缓释片 人参 丹参 麦冬 |
| DOI：10.3969/j.issn.1674-070X.2016.03.018 |
| 投稿时间：2015-12-22 |
| 基金项目:湖南省自然科学基金资助项目（13JJ5020）。 |
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| Clinical Observation of Yixinshu Capsule combined with Metoprolol Sustained-Tablets in Treatment of Premature Ventricular Beat in Patients with Coronary Heart Disease |
| LUO Yangping,TANG Mingxiang,WANG Peng,Yan Qiulin |
| (Hunan People's Hospital, Changsha, Hunan 410002, China;Hunan University of Chinese Medicinne, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the curative effect of Yixinshu capsule combined with metoprolol sustained-tablets in patients with premature ventricular beat (PVB) of coronary heart disease. Methods 100 patients with PVB of coronary heart disease were randomly divieded into the observation group (Yixinshu capsule combined with metoprolol sustained-tablets) and control group (metoprolol tablet), the curative course for 4 weeks. The clinical symptoms, changes of 24 h dynamic electrocardiogram and QT dispersion before and after treatment were observed. Results The number of premature ventricular beatin two groups were reduced (P<0.01) and the observation group was below the control group (P<0.05). better in the study group than in the control group (P<0.05). The total efficacy rate of observation group was 75.0%, the total efficacy rate of control group was 57.1%, there were significant differences between the two groups (P<0.05). The total efficacy rate of observation group in improving clinical symptoms was 62.5%, the observation group was 55.1%, there was statistically significant between the two groups (P<0.05). There were significant differences between the two groups in improving TCM syndromes (P<0.05), and the curative efficacy of observation group was better than the control group. Compared with the control group, the number of QTd and corrected QTd in observation group were obviously reduced (P<0.01). Conclusion Yixinshu capsule combined with metoprolol sustained-tablets show remarkable efficacy on treatment of the PVB of coronary heart disease. It also can reduce the QT dispersion and control the inciedence of malignant arrhythmia. |
| Key words: coronary heart disease premature ventricular beat Yixinshu capsule metoprolol sustained-tablets ginseng Salvia miltiorrhiza Radix Ophiopogonis |
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