| 引用本文: |
何玉清, 何兴辉, 郑文振.沐发舒乳联合穴位电针治疗雄激素性脱发的临床疗效和机制研究[J].湖南中医药大学学报,2026,46(5):939-945[点击复制] |
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| 沐发舒乳联合穴位电针治疗雄激素性脱发的临床疗效和机制研究 |
| 何玉清,何兴辉,郑文振 |
| (广东医科大学皮肤研究所, 广东 东莞 523400;东莞市寮步医院, 广东 东莞 523400) |
| 摘要: |
| 目的 探讨沐发舒乳联合穴位电针治疗雄激素性脱发（AGA）的临床疗效，并分析其作用机制。方法 前瞻性选取2022年9月至2024年9月就诊于东莞市寮步医院的318例AGA患者为研究对象，采用随机数字表法将其分为对照组（常规治疗方案）、试验组（沐发舒乳+常规治疗方案）及联合组（沐发舒乳+穴位电针），每组106例。治疗结束后比较3组临床疗效及不良反应，比较治疗前后AGA症状评分、趋化因子[C-X-C型趋化因子配体（C-X-C chemokine ligand, CXCL）10、CXCL12及血小板衍生生长因子（PDGF）水平]及免疫因子（CD3+、CD4+、CD8+）水平。结果 与对照组和试验组比较，联合组临床总有效率升高（P＜0.05）。与治疗前比较，治疗后对照组、试验组、联合组雄激素性脱发症状评分各项评分以及CXCL10水平均降低（P＜0.05），CXCL12、PDGF、CD3+、CD4+、CD4+/CD8+比值升高（P＜0.05）。与试验组比较，联合组雄激素性脱发症状评分各项评分以及CXCL10水平均降低（P＜0.05），CXCL12、PDGF、CD3+、CD4+、CD4+/CD8+比值升高（P＜0.05）。3组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 沐发舒乳联合穴位电针治疗AGA具有明确疗效，该联合方案通过调控趋化因子与免疫因子水平，优化毛囊生长微环境，促进毛囊修复与再生，进而改善患者毛发密度、直径、脱落量等症状体征，且临床疗效优于常规治疗方案。 |
| 关键词: 雄激素性脱发|沐发舒乳|穴位电针|脱发症状评分|趋化因子|免疫因子|不良反应 |
| DOI：10.3969/j.issn.1674-070X.2026.05.009 |
| 投稿时间：2025-12-04 |
| 基金项目:东莞市社会发展科技（重点）项目（20221800906082）。 |
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| Clinical efficacy and mechanism study of Mufashu Lotion combined with acupoint electroacupuncture in treating androgenetic alopecia |
| HE Yuqing, HE Xinghui, ZHENG Wenzhen |
| (Institute of Dermatology, Guangdong Medical University, Dongguan, Guangdong 523400, China;Dongguan Liaobu Hospital, Dongguan, Guangdong 523400, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of Mufashu Lotion combined with acupoint electroacupuncture in treating androgenetic alopecia (AGA) and to analyze its mechanism of action. Methods A total of 318 AGA patients treated at Dongguan Liaobu Hospital from September 2022 to September 2024 were prospectively selected as study subjects. They were randomly divided into control group (conventional treatment regimen), experimental group (Mufashu Lotion+ conventional treatment regimen) and combination group (Mufashu Lotion+ acupoint electroacupuncture) using a random number table method, with 106 patients in each group. After treatment, the three groups were compared in terms of clinical efficacy and adverse reactions. Additionally, comparisons were made before and after treatment regarding AGA symptom scores, levels of chemokines [C-X-C chemokine ligand 10 (CXCL10), C-X-C chemokine ligand 12 (CXCL12), platelet derived growth factor (PDGF)], and immune factors (CD3+, CD4+, CD8+). Results Compared with the control group and the experimental group, the combination group showed significantly higher total clinical efficacy rate (P<0.05). After treatment, compared with before treatment, the control group, experimental group, and combination group all exhibited decreases in AGA symptom scores and CXCL10 levels, and increases in CXCL12, PDGF, CD3+, CD4+, and CD4+/CD8+ ratio (P<0.05). Compared with the experimental group, the combination group showed lower AGA symptom scores and CXCL10 levels (P<0.05), and higher levels of CXCL12, PDGF, CD3+, CD4+, and CD4+/CD8+ ratio (P<0.05). The incidence of adverse reactions was similar among the three groups, with no statistically significant difference (P>0.05). Conclusion Mufashu Lotion combined with acupoint electroacupuncture has definite efficacy in treating AGA. This combined regimen improves the perifollicular microenvironment for hair growth by modulating chemokine and immune factor levels, promotes hair follicle repair and regeneration, and subsequently ameliorates clinical signs and symptoms such as hair density, diameter, and shedding. Its clinical efficacy is superior to that of conventional treatment regimens. |
| Key words: androgenetic alopecia|Mufashu Lotion|acupoint electroacupuncture|alopecia symptom score|chemokine|immune factor|adverse reaction |
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