| 引用本文: |
黄观明, 王菁菁, 楚扬, 伍锋, 刘浩琪, 崔海明.从“线粒体功能障碍-氧化应激”探析“气火失衡”论治心房颤动[J].湖南中医药大学学报,2025,45(9):1716-1722[点击复制] |
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| 从“线粒体功能障碍-氧化应激”探析“气火失衡”论治心房颤动 |
| 黄观明,王菁菁,楚扬,伍锋,刘浩琪,崔海明 |
| (上海中医药大学附属岳阳中西医结合医院, 上海 200437) |
| 摘要: |
| 心房颤动是一种常见的心房快速性心律失常疾病，是脑卒中、心力衰竭、心肌梗死等疾病的重要危险因素，其发病率正在逐年上升，对国民健康构成严重危害。李东垣提出“火与元气不两立”理论，本文以此理论为切入点，认为元气-阴火失衡为心房颤动发生发展的病机核心，并联系“脾-线粒体相关”学说，将“元气虚损-线粒体功能障碍”“阴火内生-氧化应激”与“气火失衡-心脏重构”结合进行阐释，提出心房颤动起始期应注重治病求本，补脾益气以防火生；心房颤动病进期应重视辅以治标，升阳散火以防气耗，以期拓宽中医药精准化防治心房颤动的思路。 |
| 关键词: 心房颤动 线粒体 氧化应激 元气 阴火 气火失衡 心脏重构 |
| DOI：10.3969/j.issn.1674-070X.2025.09.018 |
| 投稿时间：2025-05-11 |
| 基金项目:国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023065); 上海市科学技术委员会科研计划项目(19DZ1930404)。 |
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| Exploring the treatment of atrial fibrillation from the perspective of “qi and fire imbalance” based on “mitochondrial dysfunction-oxidative stress” |
| HUANG Guanming, WANG Jingjing, CHU Yang, WU Feng, LIU Haoqi, CUI Haiming |
| (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China) |
| Abstract: |
| Atrial fibrillation（AF） is a common atrial tachyarrhythmia and a significant risk factor for stroke, heart failure,myocardial infarction, and other diseases. Its incidence is rising year by year, posing a serious threat to national health. LI Dongyuan proposed the theory of "yin fire and Yuan-primordial qi cannot coexist." Based on this theory, this paper believes that the imbalance between Yuan-primordial qi and yin fire is the core pathogenesis in the onset and progression of AF. By integrating the "spleen-mitochondria correlation" theory, this paper elaborates on the connections between "Yuan-primordial qi deficiency and mitochondrial dysfunction," "internal generation of yin fire and oxidative stress," and "qi and fire imbalance and cardiac remodeling." It is proposed that in the initial stage of AF, emphasis should be placed on treating the root cause of the disease,tonifying the spleen and supplementing qi to prevent the generation of yin fire; in the progressive stage of AF, attention should also be paid to treating the manifestations, ascending yang and dispersing fire to prevent the qi consumption. This approach aims to broaden the ideas for the precise prevention and treatment of AF with Chinese medicine. |
| Key words: atrial fibrillation mitochondrion oxidative stress Yuan-primordial qi yin fire qi and fire imbalance cardiac remodeling |
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