| 引用本文: |
李泽威, 汤洋, 宋浩, 黄仪, 谭洋, 邝鸣, 裴刚.从程序性细胞死亡的分子机制中探讨中药活性成分干预肝纤维化研究[J].湖南中医药大学学报,2025,45(10):2007-2020[点击复制] |
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| 从程序性细胞死亡的分子机制中探讨中药活性成分干预肝纤维化研究 |
| 李泽威,汤洋,宋浩,黄仪,谭洋,邝鸣,裴刚 |
| (湖南中医药大学药学院, 湖南 长沙 410208;湖南省普通高等学校中药现代化研究重点实验室, 湖南 长沙 410208) |
| 摘要: |
| 肝纤维化是多种慢性肝病进展至肝硬化乃至肝癌的关键病理环节，其特征是细胞外基质的过度沉积。相关研究表明，肝细胞经历不同形式的程序性细胞死亡（PCD），包括凋亡、坏死性凋亡、自噬、焦亡、铁死亡、铜死亡等，这些死亡方式加剧炎症反应与纤维化进程。而中药活性物质在调控PCD干预肝纤维化方面有着显著疗效。因此，本文总结了不同PCD通路的发生机制和中药活性成分干预的机制研究进展，以期为中药活性物质调节各PCD治疗纤维化的研究提供科学依据。 |
| 关键词: 程序性细胞死亡 肝纤维化 分子机制 中药 活性成分 |
| DOI：10.3969/j.issn.1674-070X.2025.10.030 |
| 投稿时间：2025-05-02 |
| 基金项目:国家自然科学基金面上项目（82174271）；湖南省教育厅科学研究项目（24B0336）。 |
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| Exploring the intervention of active ingredients from Chinese medicines in liver fibrosis through the molecular mechanisms of programmed cell death |
| LI Zewei, TANG Yang, SONG Hao, HUANG Yi, TAN Yang, KUANG Ming, PEI Gang |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory of Modern Research of TCM, Education Department of Hunan Province, Changsha, Hunan 410208, China) |
| Abstract: |
| Liver fibrosis is a key pathological link in the progression of various chronic liver diseases to cirrhosis and even liver cancer, characterized by excessive deposition of extracellular matrix. Studies have shown that hepatocytes undergo different forms of programmed cell death (PCD), including apoptosis, necroptosis, autophagy, pyroptosis, ferroptosis, and cuproptosis, which exacerbate the inflammatory responses and accelerate the fibrotic process. Active ingredients derived from Chinese medicines have shown significant efficacy in regulating PCD to intervene in liver fibrosis. Therefore, this paper summarizes the mechanistic roles of the aforementioned PCD forms in the progression of liver fibrosis and reviews recent research progress on active ingredients derived from Chinese medicines that target these pathways. The aim is to offer a scientific basis for the prevention and treatment of fibrosis using Chinese medicine. |
| Key words: programmed cell death liver fibrosis molecular mechanism Chinese medicines active ingredients |
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