| 引用本文: |
张雅婷, 储继军.储继军基于“脾肾互赞”理论治疗肥胖型卵巢储备功能减退性不孕的经验[J].湖南中医药大学学报,2025,45(10):1992-1997[点击复制] |
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| 储继军基于“脾肾互赞”理论治疗肥胖型卵巢储备功能减退性不孕的经验 |
| 张雅婷,储继军 |
| (安徽中医药大学第一临床医学院, 安徽 合肥 230012;安徽中医药大学第一附属医院, 安徽 合肥 230031) |
| 摘要: |
| 卵巢储备功能减退（DOR）表现为卵母细胞数量减少和（或）质量下降，并伴随生殖内分泌功能紊乱，导致月经异常及不孕。现代医学证实，肥胖可通过胰岛素抵抗、慢性炎症、氧化应激及脂肪因子失调等多途径扰乱下丘脑-垂体-卵巢轴，损害卵母细胞质量并加速卵泡闭锁，从而导致DOR。储继军教授从“脾肾互赞”理论出发，指出“脾肾两虚、痰湿内盛”是肥胖型DOR不孕的核心病机，临证采用健脾益肾之法，通过调节“脾肾互赞”功能以改善卵巢储备功能，为肥胖型DOR的治疗提供新的治疗思路和方法。 |
| 关键词: 卵巢储备功能减退 肥胖 不孕症 脾肾互赞 健脾益肾 |
| DOI：10.3969/j.issn.1674-070X.2025.10.028 |
| 投稿时间：2025-06-25 |
| 基金项目:国家中医药管理局李伟莉全国名老中医药专家传承工作室基金资助项目（国中医药人教函〔2022〕75号）；安徽省卫生健康科研项目（AHWJ2023A30188）。 |
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| CHU Jijun's experience in treating infertility due to obesity-related diminished ovarian reserve based on the theory of "spleen-kidney mutual promotion" |
| ZHANG Yating, CHU Jijun |
| (The First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China;The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China) |
| Abstract: |
| Diminished ovarian reserve (DOR) is characterized by a decrease in the quantity and/or quality of oocytes, accompanied by reproductive endocrine dysfunction, leading to menstrual abnormalities and infertility. Modern medicine has confirmed that obesity can disrupt the hypothalamic-pituitary-ovarian (HPO) axis through multiple pathways, such as insulin resistance (IR), chronic inflammation, oxidative stress, and adipokine dysregulation. This disruption impairs oocyte quality and accelerates follicular atresia, ultimately resulting in DOR. Based on the theory of "spleen-kidney mutual promotion," Professor CHU Jijun points out that "deficiency of the spleen and kidney, and internal exuberance of phlegm-dampness" are the core pathogenesis of infertility due to obesity-related DOR. In clinical practice, he adopts the method of strengthening the spleen and tonifying the kidney to regulate the function of "spleen-kidney mutual promotion," thereby improving ovarian reserve function. This approach provides new insights and methods for treating obesity-related DOR. |
| Key words: diminished ovarian reserve obesity infertility spleen-kidney mutual promotion strengthening the spleen and tonifying the kidney |
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