| 引用本文: |
练泳慷, 罗俊杰, 张富雄, 陈宏.基于“微生物-肠-脑轴”探讨从脾论治儿童注意缺陷多动障碍[J].湖南中医药大学学报,2025,45(10):1929-1936[点击复制] |
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| 基于“微生物-肠-脑轴”探讨从脾论治儿童注意缺陷多动障碍 |
| 练泳慷,罗俊杰,张富雄,陈宏 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040) |
| 摘要: |
| 注意缺陷多动障碍（ADHD）是以注意力缺陷、多动、冲动为主要表现的神经发育障碍。中医学认为，“心肝有余，脾肾不足”为ADHD的主要病机，脾虚导致水谷运化失调，进而引发肠道菌群紊乱和免疫功能异常。“微生物-肠-脑轴”（MGBA）理论为解析中医学“从脾论治”提供了新视角。本文基于MGBA探讨脾虚在儿童ADHD发病机制中的作用，论述中医药通过调控肠道菌群、调节神经递质释放及免疫调节等多途径干预ADHD的有效机制。在此基础上，进一步总结从脾论治ADHD的三大治法：补脾益气、健脾化痰、运脾柔肝，以期为中医临床防治ADHD提供新的研究思路。 |
| 关键词: 注意缺陷多动障碍 微生物-肠-脑轴 肠道菌群 脾虚 痰瘀互结 从脾论治 |
| DOI：10.3969/j.issn.1674-070X.2025.10.017 |
| 投稿时间：2025-04-14 |
| 基金项目:中国博士后科学基金第13批特别资助项目（2020T130178）。 |
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| Exploring spleen-focused treatment for pediatric attention deficit hyperactivity disorder based on "microbiota-gut-brain axis" theory |
| LIAN Yongkang, LUO Junjie, ZHANG Fuxiong, CHEN Hong |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The First Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China) |
| Abstract: |
| Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder mainly characterized by inattention, hyperactivity, and impulsivity. TCM believes that "the heart and liver excess while the spleen and kidney deficiency" constitutes the core pathogenesis of ADHD. The spleen deficiency leads to dysfunction in the transportation and transformation of water and food, subsequently causing gut microbiota dysbiosis and immune dysfunction. The "microbiota-gut-brain axis" (MGBA) theory provides a novel perspective for interpreting "spleen-focused treatment of ADHD" in TCM. Based on the MGBA, this paper explores the role of spleen deficiency in the pathogenesis of ADHD in children and discusses the effective mechanisms by which TCM intervenes in ADHD through multiple pathways, including regulating intestinal microbiota, modulating neurotransmitter release, and modulating immune function. Furthermore, it summarizes three major spleen-focused treatments: tonifying the spleen and benefiting qi, strengthening the spleen and transforming phlegm, and activating the spleen and soothing the liver, aiming to provide new research insights for the clinical prevention and treatment of ADHD with TCM. |
| Key words: attention deficit hyperactivity disorder microbiota-gut-brain axis gut microbiota spleen deficiency intertwined phlegm and blood stasis spleen-focused treatment |
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