| 引用本文: |
伍宸希, 彭建豪, 陈展讷, 周沁婕, 曹知勇, 方刚, 庞宇舟.庞宇舟教授基于“毒虚致病”理论辨治癌因性疲乏[J].湖南中医药大学学报,2026,46(6):1271-1276[点击复制] |
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| 庞宇舟教授基于“毒虚致病”理论辨治癌因性疲乏 |
| 伍宸希,彭建豪,陈展讷,周沁婕,曹知勇,方刚,庞宇舟 |
| (广西中医药大学, 广西 南宁 530001) |
| 摘要: |
| 癌因性疲乏（CRF）是与癌症本身或其治疗相关的不良症状，与癌症患者死亡率显著相关。本文系统总结了庞宇舟教授基于“毒虚致病”理论对CRF的病机认识与辨治经验。庞宇舟教授认为癌症由“虚”开始，后毒邪聚集内伏所致；癌毒损及“三道”“两路”，气血津液运行受阻，脏腑功能失调，故患者出现各种疲乏表现。庞宇舟教授临证将CRF分为三期：初期“虚致毒恋”（癌毒内伏，道路失畅）、中期“毒致虚甚”（毒势愈张，损正伤元）、后期“毒窜虚衰”（癌毒侵蚀，脏腑衰败）。根据“毒”“虚”动态变化确立了“持续扶正、择时攻毒、随症治之”的治疗法则，强调补虚贯穿始终，根据邪正盛衰适时攻毒，并随症灵活化裁方药。附验案一则加以阐明，以期为治疗CRF提供新思路。 |
| 关键词: 癌因性疲乏 毒虚致病 三道 两路 分期论治 辨治思路 庞宇舟 |
| DOI：10.3969/j.issn.1674-070X.2026.06.026 |
| 投稿时间：2026-03-20 |
| 基金项目:庞宇舟全国名老中医药专家传承工作室（国中医药办人教函〔2022〕75号）；国家中医药管理局高水平中医药重点学科建设项目——少数民族医学（壮医学）（zyyzdxk-2023164）；桂派中医药传承创新团队——壮医毒病临床医学研究与应用创新团队（桂中医〔2023〕23号）；广西中医药多学科交叉创新团队——壮医毒病临床医学研究与应用创新团队（GZKJ2304）；庞宇舟桂派中医大师传承工作室（GZY2024007）。 |
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| Professor PANG Yuzhou's experience in differentiation and treatment of cancer-related fatigue based on the theory of “toxin-deficiency pathogenesis” |
| WU Chenxi, PENG Jianhao, CHEN Zhanne, ZHOU Qinjie, CAO Zhiyong, FANG Gang, PANG Yuzhou |
| (Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China) |
| Abstract: |
| Cancer-related fatigue (CRF) is an adverse symptom associated with cancer itself or its treatment, significantly correlated with mortality in cancer patients. This article systematically summarizes Professor PANG Yuzhou's understanding of the pathogenesis of CRF and his clinical experience in its differentiation and treatment based on the "toxin-deficiency pathogenesis" theory. Professor PANG believes that cancer arises from deficiency, followed by the accumulation and latent retention of toxic pathogens. Cancer toxins impair the functional network of the "three channels" and "two pathways" (san dao and liang lu), obstructing the circulation of qi, blood, and body fluids and disrupting zang-fu functions, thereby giving rise to various manifestations of fatigue. In clinical practice, CRF is classified into three stages: "deficiency leading to toxin attacking" (latent accumulation of cancer toxin with impaired circulation through the pathways), "toxin aggravating deficiency" (progressive intensification of toxin damaging healthy qi and impairing Yuan-primordial qi), and "toxin dissemination with deficiency waning" (invasive spread of cancer toxin accompanied by functional decline of the zang-fu organs). Based on the dynamic interplay between toxin and deficiency, he proposes the therapeutic principle of "continuously reinforcing healthy qi, eliminating toxins at appropriate stages, and modifying treatment according to symptom presentation". He emphasizes that deficiency-tonifying should be maintained throughout the entire course of treatment, while toxin-removing therapies should be applied according to the waxing and waning of anti-pathogenic qi and pathogenic factors, with formulas flexibly modified in accordance with specific clinical manifestations. A verified medical record is presented to illustrate this approach and provide new insights into the treatment of CRF. |
| Key words: cancer-related fatigue toxin-deficiency pathogenesis san dao (three channels) liang lu (two pathways) stage-based differentiation and treatment differentiation and treatment strategy PANG Yuzhou |
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