| 引用本文: |
王浩贤, 李久现, 刘妍, 张柯, 王玉玉.基于“微生物-肠-脑轴”理论探讨从心脾论治卵巢储备功能减退的研究进展[J].湖南中医药大学学报,2026,46(2):426-432[点击复制] |
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| 基于“微生物-肠-脑轴”理论探讨从心脾论治卵巢储备功能减退的研究进展 |
| 王浩贤,李久现,刘妍,张柯,王玉玉 |
| (河南中医药大学第一附属医院妇产科, 河南 郑州 450000;河南中医药大学第一临床医学院, 河南 郑州 450000) |
| 摘要: |
| 卵巢储备功能减退（DOR）作为女性常见的生殖内分泌疾病之一，其发病机制尚未完全明确。最新研究表明，以肠道菌群为主的微生物组学与DOR的发生密切相关。中医学认为，DOR的发病既责之于肾元亏虚，又因于心、脾功能失常，调补心脾可有效改善DOR的临床症状。本文基于“微生物-肠-脑轴”理论，总结中医药从心脾论治DOR的作用机制，以期为中医药治疗DOR提供新思路。 |
| 关键词: 卵巢储备功能减退 微生物-肠-脑轴 心脾 肠道菌群 中医药 神经递质 |
| DOI：10.3969/j.issn.1674-070X.2026.02.030 |
| 投稿时间：2025-09-08 |
| 基金项目:河南省医学科技攻关计划项目(LHGJ20230689);河南省卫生健康委员会国家中医临床研究基地科研专项(2022JDZX011)。 |
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| Research progress on treating diminished ovarian reserve from the perspective of the heart and spleen based on the “microbial-gut- brain axis” theory |
| WANG Haoxian, LI Jiuxian, LIU Yan, ZHANG Ke, WANG Yuyu |
| (Obstetrics and Gynecology Department, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China;The First Clinical Medical School, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China) |
| Abstract: |
| Diminished ovarian reserve (DOR), as one of the common reproductive endocrine diseases in women, has an incompletely elucidated pathogenesis. Recent studies have indicated a close association between microbiomics, primarily centered around the gut microbiota, and the occurrence of DOR. TCM believes that the pathogenesis of DOR is attributed to both kidney essence deficiency and dysfunction of the heart and spleen. Regulating and nourishing the heart and spleen can effectively ameliorate the clinical symptoms of DOR. Based on the "microbiome-gut-brain axis" theory, this article summarizes the mechanisms underlying TCM treatment of DOR from the perspective of the heart and spleen, aiming to provide novel insights for TCM interventions in DOR management. |
| Key words: diminished ovarian reserve microbial-gut-brain axis the heart and spleen gut microbiota Chinese Medicine neurotransmitters |
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