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高磅礴, 宣翔虎, 苏玉凤, 陈晓洁, 智勇.热敏灸联合息风化痰方治疗后循环缺血性眩晕的临床观察[J].湖南中医药大学学报,2026,46(2):317-322[点击复制] |
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| 热敏灸联合息风化痰方治疗后循环缺血性眩晕的临床观察 |
| 高磅礴,宣翔虎,苏玉凤,陈晓洁,智勇 |
| (滁州市第一人民医院中医科, 安徽 滁州 239001;新疆医科大学中医学院, 新疆 乌鲁木齐 830017;新疆四七四医院针灸科, 新疆 乌鲁木齐 830000) |
| 摘要: |
| 目的 探讨热敏灸联合息风化痰方治疗后循环缺血性眩晕（PCIV）的临床疗效。方法 选择滁州市第一人民医院2020年2月至2024年2月收治的PCIV患者104例，随机均分为2组，治疗期间每组脱落2例。对照组（50例）予以常规西医治疗，观察组（50例）在此基础上予以热敏灸联合息风化痰方治疗，疗程均为2周。比较两组患者治疗前后的中医证候评分、眩晕评估评分量表（DARS）评分、左侧椎动脉（LVA）平均血流速度、右侧椎动脉（RVA）平均血流速度、基底动脉（BA）平均血流速度、血清内皮素-1（ET-1）、一氧化氮（NO）、降钙素基因相关肽（CGRP）水平，并比较两组患者治疗后的临床疗效、复发情况及治疗期间的不良反应情况。结果 治疗后，两组患者中医证候评分、DARS评分较治疗前降低（P＜0.01），LVA、RVA、BA平均血流速度较治疗前升高（P＜0.01），血清ET-1水平较治疗前降低（P＜0.01），血清NO、CGRP水平较治疗前升高（P＜0.01）；观察组患者中医证候评分、DARS评分均低于对照组（P＜0.01）,LVA、RVA、BA平均血流速度高于对照组（P＜0.01）,血清ET-1水平低于对照组（P＜0.01），血清NO、CGRP水平高于对照组（P＜0.01）。观察组患者治疗总有效率高于对照组（P＜0.05），复发率低于对照组（P＜0.05）。结论 热敏灸联合息风化痰方可有效缓解PCIV患者的眩晕症状，增加椎基底动脉血流量，调节血清ET-1、NO、CGRP水平，治疗效果显著。 |
| 关键词: 后循环缺血性眩晕 热敏灸 息风化痰方 脑血流动力学 内皮素-1 一氧化氮 降钙素基因相关肽 |
| DOI：10.3969/j.issn.1674-070X.2026.02.013 |
| 投稿时间：2025-06-27 |
| 基金项目:新疆维吾尔自治区中医药特色人才培养工程——青年科技人才专项科研项目(ZYQ2025010)。 |
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| Clinical observation of heat-sensitive moxibustion combined with Xifeng Huatan Formula in treating posterior circulation ischemic vertigo |
| GAO Pangbo, XUAN Xianghu, SU Yufeng, CHEN Xiaojie, ZHI Yong |
| (Department of Traditional Chinese Medicine,, The First People's Hospital of Chuzhou, Chuzhou, Anhui 239001, China;College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830017, China;Department of Acupuncture and Moxibustion, Xinjiang 474 Hospital, Urumqi, Xinjiang 830000, China) |
| Abstract: |
| Objective To explore the clinical efficacy of heat-sensitive moxibustion combined with Xifeng Huatan Formula (XFHTF) in the treatment of posterior circulation ischemic vertigo (PCIV). Methods A total of 104 PCIV patients admitted to the First People's Hospital of Chuzhou from February 2020 to February 2024 were randomly divided into two groups, with two cases dropping out from each group during the treatment. The control group (n=50) received conventional Western medicine treatment, while the observation group (n=50) additionally received heat-sensitive moxibustion combined with XFHTF. The treatment course for both groups was two weeks. TCM pattern scores, dizziness assessment rating scale (DARS) scores, average blood flow velocities of left vertebral artery (LVA), right vertebral artery (RVA), and basilar artery (BA), serum levels of endothelin-1 (ET-1), nitric oxide (NO), and calcitonin gene-related peptide (CGRP) were compared between two groups before and after treatment. Clinical efficacy and recurrence rates after treatment, as well as adverse reactions during treatment, were also compared between two groups. Results After treatment, both groups showed decreased TCM pattern scores and DARS scores compared with before treatment (P<0.01), along with increased average blood flow velocities of LVA, RVA, and BA (P<0.01), decreased serum level of ET-1, and increased serum levels of NO and CGRP (P<0.01). Compared with the control group, the observation group showed lower TCM pattern scores and DARS scores (P<0.01), higher average blood flow velocities of LVA, RVA, and BA (P<0.01), lower serum level of ET-1 (P<0.01), and higher serum levels of NO and CGRP (P<0.01). The observation group also exhibited a higher total effective rate (P<0.05) and a lower recurrence rate than the control group (P<0.05). Conclusion Heat-sensitive moxibustion combined with XFHTF can effectively alleviate dizziness symptoms in PCIV patients, increase blood flow in the vertebral basilar artery, regulate serum levels of ET-1, NO, and CGRP, and demonstrate significant therapeutic efficacy. |
| Key words: posterior circulation ischemic vertigo heat-sensitive moxibustion Xifeng Huatan Formula cerebral hemodynamics endothelin-1 nitric oxide calcitonin gene-related peptide |
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