| 引用本文: |
谢廷逸, 黄智兰, 李亚清, 唐明文, 何咏诗, 陈珠妮, 谢纬.基于“气虚痰结络瘀”探讨肺纤维化病机演变与辨治思路[J].湖南中医药大学学报,2026,46(1):134-138[点击复制] |
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| 基于“气虚痰结络瘀”探讨肺纤维化病机演变与辨治思路 |
| 谢廷逸,黄智兰,李亚清,唐明文,何咏诗,陈珠妮,谢纬 |
| (广州中医药大学第四临床医学院, 广东 深圳 518033;深圳市中医院呼吸与危重症医学科, 广东 深圳 518033) |
| 摘要: |
| 肺纤维化为慢性进行性间质性肺疾病，现代医学在阻止其病程进展及逆转肺功能损伤方面仍存在局限。本团队根据中医学“气虚痰结络瘀”理论，创新性提出肺纤维化以脾肺肾虚为病本之源，痰瘀毒结为传变之由，肺络滞损为痼疾之因，历经“虚-滞-损”的动态演变过程。依据“标本兼治，攻补兼施”的治疗理念，系统形成健脾益肺、补肾培元以扶正固本，涤痰逐瘀、攻毒散结以祛邪理滞，疏通气血、调补肺肾以和络复用的治疗思路，以期为中医药干预肺纤维化提供病机解析新视角与临床诊治新思路。 |
| 关键词: 肺纤维化 气虚痰结络瘀 “虚-滞-损” 演变规律 辨治思路 |
| DOI：10.3969/j.issn.1674-070X.2026.01.018 |
| 投稿时间：2025-07-03 |
| 基金项目:深圳市“医疗卫生三名工程”项目（SZZYSM202311001）；广东省中医药局科研课题（20251317）。 |
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| Pathogenic evolution and pattern-based treatment of pulmonary fibrosis from the perspective of "qi deficiency with phlegm retention and collateral stasis" |
| XIE Tingyi, HUANG Zhilan, LI Yaqing, TANG Mingwen, HE Yongshi, CHEN Zhuni, XIE Wei |
| (The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, China;Department of Respiratory Medicine, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong 518033, China) |
| Abstract: |
| Pulmonary fibrosis (PF) is a chronic progressive interstitial lung disease for which contemporary biomedicine still has limitations to halt disease progression or reverse lung function impairment. Based on the Chinese medicine theory of "qi deficiency with phlegm retention and collateral stasis", our team innovatively proposes that PF originates from the deficiency of the spleen, lung, and kidney as the root cause, with intertwined phlegm, blood stasis and toxin accumulation as the mechanism of progression, and lung collateral stasis and impairment as the underlying factor of the chronic intractability. It unfolds through a dynamic evolution of "deficiency-retention-impairment." In accordance with the therapeutic principle of "treating both the tip and root, reinforcing healthy qi and removing pathogenic factors simultaneously", a systematic therapeutic strategy has been developed: tonifying the spleen, and benefiting the lung, fortifying the kidney and the Yuan-primordial qi to reinforce healthy qi and strengthen the body; eliminating phlegm, expelling stasis, removing toxins and dispersing masses to eliminate pathogenic factors and unblock stagnation; soothing qi and blood, and regulating and tonifyingthe lung and kidney to harmonize meridians and facilitate restoration. This framework aims to provide a new perspective on the pathogenesis analysis and a novel clinical approach for Chinese medicine intervention in PF. |
| Key words: pulmonary fibrosis qi deficiency with phlegm retention and collateral stasis "deficiency－retention－impairment" evolution pattern pattern-based treatment strategy |
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