| 引用本文: |
张小琴, 朱智显, 陶旺, 黄湘宁, 黄家望, 喻嵘.从“脾不散精，毒损脉络”探赜代谢重编程驱动糖尿病大血管病变的机制[J].湖南中医药大学学报,2025,45(12):2358-2365[点击复制] |
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| 从“脾不散精，毒损脉络”探赜代谢重编程驱动糖尿病大血管病变的机制 |
| 张小琴,朱智显,陶旺,黄湘宁,黄家望,喻嵘 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 糖尿病大血管病变是糖尿病致死致残的核心并发症，传统降脂治疗难以改善代谢失衡。本文基于中医“脾不散精，毒损脉络”理论，提出“精微不布-浊邪内生-浊毒蕴结-蚀脉成斑”的病理轴，并聚焦“代谢重编程”这一现代生物学枢纽，揭示其连接“脾不散精”与“毒损脉络”的关键桥梁作用，进而提出以助脾散精、祛毒通络法调节“代谢重编程-清除毒性产物-修复血管内皮”的干预新策略，为糖尿病大血管病变的精准防治提供理论依据。 |
| 关键词: 糖尿病大血管病变 动脉粥样硬化 脾不散精 毒损脉络 代谢重编程 助脾散精 祛毒通络 |
| DOI：10.3969/j.issn.1674-070X.2025.12.016 |
| 投稿时间：2025-07-14 |
| 基金项目:国家自然科学基金项目（U21A20411）；湖南省自然科学基金创新研究群体项目（2024JJ1007，2024JJ5303）；湖南省中医药科研项目（B2024003）；湖南省教育厅项目（24A0263）；湖南中医药大学学科建设“揭榜挂帅”项目（22JBZ002）；2023年度湖南中医药大学校院联合基金项目（2023XYLH036）。 |
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| Mechanism of metabolic reprogramming driving diabetic macroangiopathy from the perspective of "spleen failing to disperse essence and toxins damaging the collaterals" |
| ZHANG Xiaoqin, ZHU Zhixian, TAO Wang, HUANG Xiangning, HUANG Jiawang, YU Rong |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Diabetic macroangiopathy is a core complication of diabetes mellitus that leads to death and disability, and traditional lipid-lowering therapies find it difficult to ameliorate metabolic imbalances. Based on the TCM theory of "spleen failing to disperse essence and toxins damaging the collaterals," this paper proposes a pathological axis of "failure of refined substances distribution-endogenous generation of turbid pathogens-accumulation of turbid toxins-erosion of vessels and plaque formation." Focusing on "metabolic reprogramming," a pivotal hub in modern biology, it reveals its crucial bridging role connecting "spleen failing to disperse essence" and "toxins damaging the collaterals." Subsequently, a novel intervention strategy is proposed, which involves regulating "metabolic reprogramming-clearance of toxic products-repair of vascular endothelium" through the methods of assisting the spleen in dispersing essence and eliminating toxins to unblock the collaterals. This provides a theoretical basis for the precise prevention and treatment of diabetic macroangiopathy. |
| Key words: diabetic macroangiopathy atherosclerosis spleen failing to disperse essence toxins damaging the collaterals metabolic reprogramming assisting the spleen in dispersing essence eliminating toxins to unblock the collaterals |
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