| 引用本文: |
陈瑞, 徐敏君, 路云博, 袁英棋, 初桐菲, 程龙.葛根素治疗代谢综合征作用机制研究进展[J].湖南中医药大学学报,2025,45(11):2232-2238[点击复制] |
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| 葛根素治疗代谢综合征作用机制研究进展 |
| 陈瑞,徐敏君,路云博,袁英棋,初桐菲,程龙 |
| (中国医科大学中药与生药教研室, 辽宁 沈阳 110122) |
| 摘要: |
| 代谢综合征是一组以肥胖、糖尿病、血脂异常、高血压、高尿酸血症和脂肪性肝病等聚集性发生为特征的临床症候群，其发病机制包括胰岛素抵抗、慢性炎症、氧化应激、肠道菌群紊乱及血管功能异常等多个环节。葛根素是一种从葛根中提取的有效成分，具有降血糖、改善胰岛素抵抗、扩张血管、改善肠道菌群、抗炎和抗氧化应激等功能，对肥胖、糖尿病、高血压、血脂异常、高尿酸血症和脂肪肝等疾病有一定的治疗作用，是治疗代谢综合征的主要组成成分。本文系统综述葛根素治疗代谢综合征的作用机制，为其临床应用和深入研究提供思路。 |
| 关键词: 葛根素 代谢综合征 肥胖 糖尿病 胰岛素抵抗 氧化应激 炎症 |
| DOI：10.3969/j.issn.1674-070X.2025.11.030 |
| 投稿时间：2025-07-11 |
| 基金项目:辽宁省博士科研启动基金计划项目(2023-BS-093); 辽宁省大学生创新创业训练计划项目(S202510159034)。 |
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| Research progress on the mechanism of action of puerarin in treating metabolic syndrome |
| CHEN Rui, XU Minjun, LU Yunbo, YUAN Yingqi, CHU Tongfei, CHENG Long |
| (Department of Chinese Medicine and Pharmacognosy, China Medical University, Shenyang, Liaoning 110122, China) |
| Abstract: |
| Metabolic syndrome is a clinical syndrome characterized by the clustered occurrence of obesity, diabetes,dyslipidemia, hypertension, hyperuricemia, and fatty liver disease. Its pathogenesis involves multiple links, including insulin resistance, chronic inflammation, oxidative stress, intestinal microbiota imbalance, and vascular dysfunction, among others. Puerarin,an active ingredient extracted from Gegen（Puerariae Lobatae Radix）, possesses functions such as lowering blood glucose, improving insulin resistance, dilating blood vessels, modulating intestinal microbiota, exerting anti-inflammatory effects, and combating oxidative stress. It has certain therapeutic effects on diseases including obesity, diabetes, hypertension, dyslipidemia, hyperuricemia,and fatty liver, serving as a key component in the treatment of metabolic syndrome. This article systematically reviews the mechanism of action of puerarin in the treatment of metabolic syndrome, providing insights for its clinical application and further in-depth research. |
| Key words: puerarin metabolic syndrome obesity diabetes insulin resistance oxidative stress inflammation |
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