| 引用本文: |
翟文姬, 邓立梅, 代洪绪.养心汤联合美托洛尔对心律失常患者心功能、不良反应及氧化应激反应的影响[J].湖南中医药大学学报,2025,45(5):898-903[点击复制] |
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| 养心汤联合美托洛尔对心律失常患者心功能、不良反应及氧化应激反应的影响 |
| 翟文姬,邓立梅,代洪绪 |
| (黑龙江中医药大学附属第二医院, 黑龙江 哈尔滨 150001;黑龙江省中医药科学院, 黑龙江 哈尔滨 150036) |
| 摘要: |
| 目的 探讨养心汤联合美托洛尔对心律失常患者心功能、不良反应及氧化应激反应的影响。方法 对2021年7月至2023年7月黑龙江中医药大学附属第二医院心血管二科收治的80例心律失常患者进行观察，按照随机数字表法分为对照组和研究组，每组40例。对照组给予琥珀酸美托洛尔片治疗，研究组在对照组基础上给予养心汤治疗。比较两组患者中医证候积分、心功能[左室射血分数（LVEF）、左心室收缩末径（LVESD）、左心室舒张末径（LVEDD）]、临床疗效、血清氧化应激因子[一氧化氮（NO）、丙二醛（MDA）、超氧化物歧化酶（SOD）]、心肌损伤指标[肌钙蛋白I（cTnI）、肌酸激酶同工酶（CK-MB）]、心率，以及不良反应的发生情况。结果 研究组患者的有效率高于对照组（P＜0.05），不良反应发生率低于对照组（P＜0.05）。治疗后，两组患者的LVEF、SOD、静息心率、最慢心率、24 h平均心率升高（P＜0.05），且研究组高于对照组（P＜0.05）；中医证候积分、LVESD、LVEDD、NO、MDA、cTnI、CK-MB降低（P＜0.05），且研究组低于对照组（P＜0.05）。结论 养心汤联合美托洛尔治疗能改善心律失常患者的心功能、氧化应激反应，降低不良反应发生率。 |
| 关键词: 心律失常 养心汤 美托洛尔 心功能 不良反应 氧化应激反应 |
| DOI：10.3969/j.issn.1674-070X.2025.05.016 |
| 投稿时间：2024-11-18 |
| 基金项目:黑龙江省中医药科研项目（ZHY2023-069）。 |
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| Effects of Yangxin Decoction combined with metoprolol on cardiac function, adverse reactions, and oxidative stress in patients with arrhythmia |
| ZHAI Wenji, DENG Limei, DAI Hongxu |
| (The Second Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China;Heilongjiang Academy of Chinese Medicine Sciences, Harbin, Heilongjiang 150036, China) |
| Abstract: |
| Objective To investigate the effects of Yangxin Decoction combined with metoprolol on cardiac function, adverse reactions, and oxidative stress in patients with arrhythmia. Methods A total of 80 patients with arrhythmia admitted to the Second Cardiovascular Department of the Second Hospital of Heilongjiang University of Chinese Medicine from July 2021 to July 2023 were observed. They were divided into control group and research group by the random number table method, with 40 cases in each group. The control group received Metoprolol Succinate Tablets, while the research group received Yangxin Decoction in addition to the same treatment. The TCM pattern scores, left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), clinical efficacy, serum oxidative stress factors [nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD)], myocardial injury indications [troponin I (cTnI) and creatine kinase isoenzyme (CK-MB)], heart rate, and adverse reactions were compared between the two groups. Results The effective rate of the research group was higher than that of the control group (P<0.05), and the incidence of adverse reactions was lower than that of the control group (P<0.05). After treatment, the LVEF, SOD levels, resting heart rate, slowest heart rate, and 24-h average heart rate of the two groups increased (P<0.05), with higher values observed in the research group compared to the control group (P<0.05). TCM pattern scores, LVESD, LVEDD, NO, MDA, cTnI, and CK-MB levels decreased in both groups (P<0.05), with greater reductions observed in the research group compared to the control group (P<0.05). Conclusion Yangxin Decoction combined with metoprolol can improve cardiac function, alleviate oxidative stress response, and reduce the incidence of adverse reactions in patients with arrhythmia. |
| Key words: arrhythmia Yangxin Decoction metoprolol cardiac function adverse reactions oxidative stress response |
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