| 引用本文: |
王毅华, 谢玉莲, 左京才, 高航.抗疲劳膏对肺肾阴虚型慢性阻塞性肺疾病的临床疗效、炎症因子、免疫功能的影响[J].湖南中医药大学学报,2025,45(2):376-381[点击复制] |
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| 抗疲劳膏对肺肾阴虚型慢性阻塞性肺疾病的临床疗效、炎症因子、免疫功能的影响 |
| 王毅华,谢玉莲,左京才,高航 |
| (北海市中医医院肺病科, 广西 北海 536000;广西中医药大学研究生学院, 广西 南宁 530000) |
| 摘要: |
| 目的 探讨抗疲劳膏对肺肾阴虚型慢性阻塞性肺疾病（COPD）的临床疗效、炎症因子、免疫功能的影响。方法 选取2021年1月至2024年1月于北海市中医医院就诊的96例肺肾阴虚型COPD患者，采用随机数字表法分为西药组和抗疲劳膏组，每组48例。西药组以西医治疗手段干预，抗疲劳膏组是在西药组基础上加用抗疲劳膏。比较两组患者治疗后的临床疗效，治疗前、后中医证候积分，炎症指标[降钙素（CT）、C反应蛋白（CRP）、白细胞介素-6（IL-6）]，6 min步行距离（6MWD）及免疫功能水平[免疫球蛋白IgA、 IgG、 IgM和辅助性T细胞（Th1/Th2）]。结果 抗疲劳膏组治疗后临床疗效优于西药组（P<0.05）。治疗后，两组6MWD、IgA、IgG、IgM、Th1/Th2水平高于治疗前（P<0.05），且抗疲劳膏组高于西药组（P<0.05）；治疗后，两组中医证候积分、CT、CRP、IL-6水平低于治疗前（P<0.05），且抗疲劳膏组低于西药组（P<0.05）。结论 抗疲劳膏治疗肺肾阴虚型COPD临床疗效确切，可有效改善患者临床症状及体征，抑制炎症因子水平，调节患者免疫平衡，增强患者机体免疫力，具有一定的临床应用价值。 |
| 关键词: 慢性阻塞性肺疾病 肺肾阴虚证 抗疲劳膏 炎症因子 免疫功能 临床疗效 |
| DOI：10.3969/j.issn.1674-070X.2025.02.028 |
| 投稿时间：2024-09-23 |
| 基金项目:广西壮族自治区中医药管理局自筹经费项目（GXZYZ20210046）；广西中医药大学校级面上项目（2022MS069）。 |
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| Clinical efficacy of Kang Pilao Condensed Decoction on chronic obstructive pulmonary disease of lung and kidney yin deficiency pattern and its impact on inflammatory factors and immune function |
| WANG Yihua, XIE Yulian, ZUO Jingcai, GAO Hang |
| (Department of Pulmonary Diseases, Beihai Hospital of Chinese Medicine, Beihai, Guangxi 536000, China;Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China) |
| Abstract: |
| Objective To explore the clinical efficacy of Kang Pilao Condensed Decoction on chronic obstructive pulmonary disease (COPD) of lung and kidney yin deficiency pattern and its impact on inflammatory factors and immune function. Methods Ninety-six patients with COPD of lung and kidney yin deficiency pattern who were treated in Beihai Hospital of Chinese Medicine from January 2021 to January 2024 were selected and divided into Western medicine group and Kang Pilao Condensed Decoction group using random number table method, with 48 patients in each group. The Western medicine group was intervened with western medical treatment, while the Kang Pilao Condensed Decoction group received additional Kang Pilao Condensed Decoction on the basis of the Western medicine group. The clinical efficacy after treatment, as well as the Chinese medicine pattern scores, inflammatory markers [calcitonin (CT), C-reactive protein (CRP), interleukin-6 (IL-6)], 6-minute walk distance (6MWD), and immune function levels [immunoglobulin A (IgA), IgG, IgM, and helper T cells (Th1/Th2 ratio)] before and after treatment were compared between the two groups. Results Clinical efficacy of the Kang Pilao Condensed Decoction group was superior to that of the western medicine group (P<0.05). After treatment, the levels of 6MWD, IgA, IgG, IgM, and Th1/Th2 ratio in both groups were higher than those before treatment (P<0.05), with the Kang Pilao Condensed Decoction group showing higher levels than the Western medicine group (P<0.05). Additionally, after treatment, Chinese medicine pattern scores, CT, CRP, and IL-6 levels in both groups were lower than those before treatment (P<0.05), and those in the Kang Pilao Condensed Decoction group were lower than in Western medicine group (P<0.05). Conclusion The Kang Pilao Condensed Decoction demonstrates definite clinical efficacy in treating COPD of lung and kidney yin deficiency pattern. It can effectively improve patients' clinical symptoms and signs, inhibit the levels of inflammatory factors, regulate immune balance, and enhance patients' immune function, thus possessing certain clinical application value. |
| Key words: chronic obstructive pulmonary disease lung and kidney yin deficiency pattern Kang Pilao Condensed Decoction inflammatory factors immune function clinical efficacy |
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