| 引用本文: |
吕安淇, 姜成, 杨振宇, 左婉曌, 李焱, 杨毅, 何聪, 田发念, 柯佳.基于“虚气留滞”理论探讨中药调控线粒体质量控制对肺癌的影响及研究进展[J].湖南中医药大学学报,2025,45(1):182-190[点击复制] |
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| 基于“虚气留滞”理论探讨中药调控线粒体质量控制对肺癌的影响及研究进展 |
| 吕安淇,姜成,杨振宇,左婉曌,李焱,杨毅,何聪,田发念,柯佳 |
| (湖北中医药大学中医学院, 湖北 武汉 430060;湖北中医药大学第一临床学院, 湖北 武汉 430060;湖北省中医院 湖北中医药大学附属医院, 湖北 武汉 430074;湖北时珍实验室 湖北 武汉 430060) |
| 摘要: |
| 肺癌的发病率和死亡率均居于我国癌症首位，线粒体质量控制（MCQ）可通过促进线粒体自噬和动力学改变以及破坏线粒体生物发生，从而促进肺癌的进展。肺癌为本虚标实、虚实夹杂之证，“虚气留滞”是肺癌的关键病机，与MCQ存在直接联系，“虚气”与“留滞”皆可通过MCQ失衡致使肺正常细胞的凋亡，促进肺癌细胞的侵袭与转移，从而影响肺癌的发生发展。从“虚气留滞”理论出发，结合MCQ在肺癌中的发病机制，阐述中医药干预MCQ的进展和思路，以期为中医理论的现代应用及中医药治疗肺癌提供新依据和新靶点。 |
| 关键词: 线粒体质量控制 “虚气留滞”理论 肺癌 扶正补虚 祛邪行滞 发病机制 研究进展 |
| DOI：10.3969/j.issn.1674-070X.2025.01.030 |
| 投稿时间：2024-09-02 |
| 基金项目:国家中医药管理局“凃晋文国医大师传承工作室”建设项目(国中医药办人教函[2022]245号);国家中医疫病基地项目(湖北)(国中医药医政函[2020]244号);湖北省“公共卫生青年拔尖人才培养项目”计划(鄂卫通[2021]74号);湖北省自然科学基金项目(2023AFD173)。 |
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| Effects and research progress of Chinese medicines on lung cancer through regulation of mitochondrial quality control based on the theory of "deficienct-qi stagnation" |
| LYU Anqi, JIANG Cheng, YANG Zhenyu, ZUO Wanzhao, LI Yan, YANG Yi, HE Cong, TIAN Fanian, KE Jia |
| (School of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430060, China;The First Clinical College, Hubei University of Chinese Medicine, Wuhan, Hubei 430060, China;Hubei Provincial Hospital of TCM, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan Hubei, 430074, China;Hubei Shizhen Laboratory, Wuhan Hubei 430060, China) |
| Abstract: |
| Both the incidence and mortality of lung cancer rank first among all all types of cancers in China, and mitochondrial quality control（MCQ） can promote the progression of lung cancer by facilitating mitophagy, altering mitochondrial dynamics, and disrupting mitochondrial biogenesis. Lung cancer is characterized by root deficiency and tip excess, as well as mixed deficiency and excess, with "deficienct-qi stagnation" being the key pathogenesis, which is directly related to MCQ.Both "deficienct-qi" and "stagnation" can disrupt the balance of MCQ, leading to the apoptosis of normal lung cells and promoting the invasion and metastasis of lung cancer cells, thereby affecting the occurrence and progression of the disease.This article, based on the theory of "deficienct-qi stagnation", elaborates on the progress and approaches of Chinese medicine interventions combined with the pathogenic mechanisms of MCQ in lung cancer, providing new evidence and targets for the modern application of Chinese medicine theories and the treatment of lung cancer with Chinese medicine. |
| Key words: mitochondrial quality control theory of "deficienct-qi stagnation" lung cancer reinforcing healthy qi and supplementing deficiency eliminating pathogenic factors and resolving stagnation pathogenesis research progress |
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