| 引用本文: |
王昕玥, 刘龙涛, 吴敏.从“虚瘀毒”论治肿瘤心脏病的思路探讨[J].湖南中医药大学学报,2024,44(12):2309-2314[点击复制] |
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| 从“虚瘀毒”论治肿瘤心脏病的思路探讨 |
| 王昕玥,刘龙涛,吴敏 |
| (中国中医科学院广安门医院, 北京 100053;中国中医科学院西苑医院, 北京 100091) |
| 摘要: |
| 肿瘤心脏病学是近年来出现的新兴学科，指肿瘤或抗肿瘤治疗手段引起的心血管病变，严重影响肿瘤患者的生存期及预后。目前，肿瘤心脏病治疗多遵循相应心血管病的临床指南，治疗方案亟待完善。基于“瘀毒”理论，根据肿瘤心脏病患者血液高凝状态、炎症反应活跃等特点，提出肿瘤心脏病患者“虚为本，瘀为常，毒为变”的中医病机。“虚瘀毒”三者互为因果，患者久病体虚，气血壅阻脉中，瘀血内蕴，化生热毒，瘀毒胶结，阻碍气血运行，体虚更甚。益气活血解毒中药可多途径、多靶点抑制炎症反应，改善凝血功能，保护血管内皮，从而改善心脏功能。“益气活血解毒”被提出为贯穿肿瘤心脏病全病程的治疗总则，以期为肿瘤心脏病的临床诊治提供新思路。 |
| 关键词: “瘀毒”理论 “虚瘀毒” 肿瘤心脏病 益气活血解毒 诊治思路 |
| DOI：10.3969/j.issn.1674-070X.2024.12.025 |
| 投稿时间：2024-06-01 |
| 基金项目:国家自然科学基金项目（82074254，82374281）;北京市自然科学基金项目（7172185）;中国中医科学院科技创新工程项目（CI2021A01413）;第五批中医临床优秀人才研修项目（国中医药人才函〔2022〕1号）;北京市中医药科技发展资金项目（BJZYYB-2023-73）;首都卫生发展科研专项项目（首发2024-2-4154）。 |
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| Treatment of cardio-oncologic diseases from the perspective of "deficiency, blood stasis, and toxicity" |
| WANG Xinyue, LIU Longtao, WU Min |
| (Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China) |
| Abstract: |
| Cardio-oncology, as an emerging discipline in recent years, involves the cardiovascular lesions caused by tumors or anti-tumor therapies, which seriously affect the survival and prognosis of tumor patients. Currently, treatment for cardio-oncologic diseases mostly follows the clinical guidelines for the corresponding cardiovascular diseases, and treatment protocols need improving. Based on the theory of "blood stasis and toxicity", and according to the characteristics of patients with cardio-oncologic diseases, such as hypercoagulability and active inflammatory reaction, this paper has proposed that the Chinese medicine pathogenesis of such diseases is "deficiency as the root, blood stasis as the norm, and toxicity as the change." "Deficiency, blood stasis, and toxicity" are the causes and effects of each other. That is to say, the weak constitution of patients due to long-term disease results in qi and blood blockage in the vessels, thus producing static blood. The static blood brings on the generation of heat toxin, and they clump together and hinder the circulation of qi and blood in turn, worsening the weakness of the body. Chinese medicines for tonifying qi, circulating blood, and removing toxins can inhibit the inflammatory response, regulate coagulation function, and protect the vascular endothelium through multiple pathways and targets, thus improving cardiac function. Therefore, "tonifying qi, circulating blood, and removing toxins" has been proposed as a general therapeutic principle throughout the whole course of cardio-oncologic diseases. This paper aims to provide new ideas for the clinical diagnosis and treatment of cardio-oncologic diseases. |
| Key words: theory of "blood stasis and toxicity" "deficiency,blood stasis,and toxicity" cardio-oncologic diseases tonifying qi,circulating blood,and removing toxins diagnosis and treatment ideas |
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