| 引用本文: |
杨怡, 陈伶利, 张书萌, 于子璇, 李杰.“心主血脉”探讨铜死亡在冠心病中的发病机制及中医药干预研究[J].湖南中医药大学学报,2024,44(10):1930-1936[点击复制] |
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| “心主血脉”探讨铜死亡在冠心病中的发病机制及中医药干预研究 |
| 杨怡,陈伶利,张书萌,于子璇,李杰 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学中西医结合病原生物学湖南省重点实验室, 湖南 长沙 410208) |
| 摘要: |
| 冠心病（coronary heart disease，CHD）的患病率和死亡率逐年上升，而铜死亡与CHD的形成发展具有重要关系，可通过血管损伤、引发炎症反应、增加总胆固醇水平等方式促进CHD发展。铜死亡是一种新型的、铜依赖的细胞程序化死亡方式，与氧化应激、抑制泛素-蛋白酶体系统、诱导脂酰化蛋白聚集等多种途径有关，并参与多种疾病的病理过程。铜死亡可双向致病，人体内铜缺乏或积累过多均会对健康造成影响，维持体内铜浓度平衡可能成为药物干预铜死亡的重要靶点。心主血脉是中医藏象学说的重要理论之一。从心主血脉理论出发，结合铜死亡在CHD中的发病机制，阐述中医药如何干预铜死亡进展和思路，为藏象学说现代应用及中医药治疗CHD提供新依据和新靶点。 |
| 关键词: 铜代谢 铜死亡 冠心病 中医药 心主血脉 |
| DOI：10.3969/j.issn.1674-070X.2024.10.030 |
| 投稿时间：2024-04-08 |
| 基金项目:国家自然科学基金项目(81874375);湖南省自然科学基金项目(2022JJ30430);湖南省教育厅科学研究重点项目(21A0231);湖南省普通高等学校科技创新团队支持项助。 |
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| Pathogenesis of cuproptosis in coronary heart disease and Chinese medicine intervention from the perspective of "the heart governing the blood and vessels" |
| YANG Yi, CHEN Lingli, ZHANG Shumeng, YU Zixuan, LI Jie |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Key Laboratory of Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Key Laboratory of Pathogeny Biology of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| The prevalence and mortality rates of coronary heart disease (CHD) have been increasing year by year. Cuproptosis plays a significant role in the formation and progression of CHD, promoting CHD development by inducing vascular injury, triggering inflammatory reaction, and elevating total cholesterol levels. Cuproptosis is a novel, copper-dependent form of programmed cell death associated with multiple pathways, including oxidative stress, inhibition of the ubiquitin proteasome system, and induction of lipid-acylated protein aggregation, and it is involved in the pathological processes of various diseases. Cuproptosis can lead to disease in both directions, and deficiency or excessive accumulation of copper in the human body can impact health. Thus, maintaining a balanced copper concentration in the body may become an important target for drug intervention in cuproptosis. "The heart governing the blood and vessels" is one of the important theories in the zang-xiang theory of Chinese medicine. Based on the theory and the pathogenesis of cuproptosis in CHD, this paper elucidates how Chinese medicine intervenes the progression of cuproptosis, offering new evidence and targets for the modern application of zang-xiang theory and the treatment of CHD with Chinese medicine. |
| Key words: copper metabolism cuproptosis coronary heart disease Chinese medicine the heart governing the blood and vessels |
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