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王理槐,孙银辉,陈晟,刘正艺,胡宇翔,万多,田雪飞.基于ERAD-ERSIA稳态探讨健脾益肾法干预癌症恶病质骨骼肌萎缩[J].湖南中医药大学学报,2023,43(12):2305-2312[点击复制] |
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| 基于ERAD-ERSIA稳态探讨健脾益肾法干预癌症恶病质骨骼肌萎缩 |
| 王理槐,孙银辉,陈晟,刘正艺,胡宇翔,万多,田雪飞 |
| (湖南中医药大学中西医结合学院, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 癌症恶病质（cancer cachexia，CC）是癌症中晚期常见的致死并发症。现代医学营养支持只能在一定程度上缓解CC，总体疗效欠佳。CC属于中医学“虚劳”范畴，脾肾亏虚为主要病机。健脾益肾法能有效干预CC，但其具体机制尚未完全阐明。内质网应激（endoplasmic reticulum stress，ERS）与CC骨骼肌萎缩息息相关。内质网应激相关性降解（ER-associated degradation，ERAD）在适度的ERS时被激活，能有效恢复肌细胞内环境稳态，维持肌细胞存活。但内质网应激性凋亡（endoplasmic reticulum stress induced apoptosis，ERSIA）在持续或者高强度ERS情况下被激活，引起肌细胞凋亡，从而导致骨骼肌萎缩。从ERAD-ERSIA稳态探讨健脾益肾法干预CC骨骼肌萎缩，为中医健脾益肾法改善CC的机制研究提供思路。 |
| 关键词: 癌症 恶病质 内质网应激 内质网应激相关性降解 骨骼肌萎缩 健脾益肾 |
| DOI：10.3969/j.issn.1674-070X.2023.12.024 |
| 投稿时间：2023-12-01 |
| 基金项目:湖南省自然科学基金项目（2021JJ30525）；湖南中医药大学一流学科开放基金项目（2019ZXYJH03）；湖南省科学技术厅湖南省中医肿瘤临床研究中心平台项目（2021SK4023）。 |
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| Method of strengthening the spleen and benefiting the kidney for intervening skeletal muscle atrophy in cancer cachexia based on ERAD-ERSIA homeostasis |
| WANG Lihuai,SUN Yinhui,CHEN Sheng,LIU Zhengyi,HU Yuxiang,WAN Duo,TIAN Xuefei |
| (School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Cancer cachexia(CC) is a common fatal complication of advanced cancer, and modern medical nutritional support can only alleviate CC to a certain extent with poor efficacy on the whole. CC belongs to the category of "deficiency" in Chinese medicine with deficiency of the spleen and kidney as its main pathogenesis. For now, the method of strengthening the spleen and benefiting the kidney can effectively intervene CC, but its specific mechanism remains to be elucidated. It is believed that endoplasmic reticulum stress(ERS) is closely related to CC skeletal muscle atrophy. Furthermore, ER-associated degradation(ERAD) pathways can be activated under moderate ERS, which is conducive to the restoration of homeostasis and survival of muscle cells. However, if endoplasmic reticulum stress induced apoptosis(ERSIA) is activated under sustained or high intensity ERS, it will cause apoptosis of muscle cells and lead to skeletal muscle atrophy. This paper discusses the method of strengthening the spleen and benefiting the kidney for intervening CC skeletal muscle atrophy by ERAD-ERSIA homeostasis, providing ideas for the mechanism study on TCM method of strengthening the spleen and benefiting the kidney in improving CC. |
| Key words: cancer cachexia endoplasmic reticulum stress ER-associated degradation skeletal muscle atrophy strengthening the spleen and benefiting the kidney |
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