| 引用本文: |
塔吉姑丽·吐逊,张文定,节阳华.中医药调控中晚期结直肠癌炎性及免疫微环境的研究进展[J].湖南中医药大学学报,2023,43(9):1737-1741[点击复制] |
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| 中医药调控中晚期结直肠癌炎性及免疫微环境的研究进展 |
| 塔吉姑丽·吐逊,张文定,节阳华 |
| (新疆医科大学第四临床医学院, 新疆 乌鲁木齐 830000;新疆医科大学附属中医医院, 新疆 乌鲁木齐 830000) |
| 摘要: |
| 肿瘤微环境是指适合肿瘤生存的细胞环境，在肿瘤的发生发展转移中起较重要作用，炎性微环境与免疫微环境则是其中重要组成部分。慢性炎症与免疫抑制是肿瘤微环境的两个核心特征。对肿瘤炎性、免疫微环境进行干预及调控，是近几年来肿瘤研究界中较受关注的研究领域之一。现有研究多以津液理论、癌毒理论、护场理论解释中晚期结直肠癌炎性微环境，以营卫理论、阴阳理论解释免疫微环境，以扶正固本、清热解毒、活血化瘀、散结化痰法来调控中晚期结直肠癌微环境。本文对近几年来中医药认识及调控中晚期结直肠癌炎性、免疫微环境的研究现状进行归纳与分析，以期为今后相关研究提供思路与参考。 |
| 关键词: 中医药 中晚期结直肠癌 炎性微环境 免疫微环境 扶正固本 解毒化瘀 |
| DOI：10.3969/j.issn.1674-070X.2023.09.029 |
| 投稿时间：2023-05-07 |
| 基金项目:新疆维吾尔自治区自然科学基金面上基金项目（2022D01C560）。 |
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| Research progress on Chinese medicine in regulating inflammatory and immune microenvironment of advanced colorectal cancer |
| Tajiguli TUXUN,ZHANG Wending,JIE Yanghua |
| (The Fourth Clinical Medical College, Xinjiang Medical University, Wulumuqi, Xinjiang 830000, China;The Hospital of Chinese Medicine of Xinjiang Medical University, Wulumuqi, Xinjiang 830000, China) |
| Abstract: |
| Tumor microenvironment refers to the cellular environment suitable for tumor survival. Inflammatory microenvironment and immune microenvironment are important components, playing an important role in the occurrence, development, and metastasis of tumors. Chronic inflammation and immune suppression are two core features of tumor microenvironment. Intervention and regulation of tumor inflammation and immune microenvironment has been one of the research areas of great concern in the field of cancer research community in recent years. Existing studies have mostly used the theories of body fluid, cancer toxin, and field protection to explain the inflammatory microenvironment of middle- and late-stage colorectal cancer, the theory of Ying-nutrients and Wei-defence, and the theory of yin and yang to explain the immune microenvironment. The microenvironment of middle- and late-stage colorectal cancer was regulated by the methods of reinforcing healthy qi to strengthen the body, clearing heat and removing toxins, circulating blood and transforming stasis, and resolving masses and transforming phlegm. The paper summarized and analyzed the current research status of Chinese medicine in understanding and regulating the inflammatory and immune microenvironment of advanced colorectal cancer in recent years, in order to provide ideas and references for future related research. |
| Key words: Chinese medicine middle- and late-stage colorectal cancer inflammatory microenvironment immune microenvironment reinforcing healthy qi to strengthen the body removing toxins and transforming stasis |
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