| 引用本文: |
廖端芳,张佳,卢光明,李凯.DNA甲基化谱：流淌的生命脉律——纪念DNA双螺旋结构发现70周年[J].湖南中医药大学学报,2023,43(7):1315-1319[点击复制] |
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| DNA甲基化谱：流淌的生命脉律——纪念DNA双螺旋结构发现70周年 |
| 廖端芳,张佳,卢光明,李凯 |
| (湖南中医药大学个体化诊疗技术国家(联合)工程研究中心, 湖南 长沙 410208;湖南中医药大学湘产大宗药材品质评价湖南省重点实验室, 湖南 长沙 410208;中国人民解放军东部战区总医院, 南京大学医学院附属金陵医院, 江苏 南京 210016) |
| 摘要: |
| 70年前，随着DNA双螺旋结构的发现，人类进入基因组时代；21世纪初，人类基因组测序完成及对转录组、蛋白质组和表观遗传的研究，人类继而进入后基因组时代；近年对DNA甲基化的深入研究，预示更为神秘宽广的表观遗传组学时代已经到来。人体血液中大量存在的甲基化DNA构成甲基化谱，作为一个整合性指标，有如一曲流淌的生命脉律，反映不同细胞的生理或病理状态。精准分析甲基化谱，具有诊断疾病特别是肿瘤早筛早诊的价值；同时可作为人类健康、乃至天赋的量化评估指标；也可用于中医体质辨识与证型分类及中药材溯源、真伪识别和品种改良。本文介绍表观遗传组学时代甲基化谱的重要意义，以纪念DNA双螺旋结构发现70周年。 |
| 关键词: DNA甲基化 甲基化谱 游离核酸 表观遗传 肿瘤早筛 |
| DOI：10.3969/j.issn.1674-070X.2023.07.026 |
| 投稿时间：2023-01-19 |
| 基金项目:湖南省教育厅重大病毒感染性疾病防治科技攻关项目（湘财教指〔2020〕17号文件）；湖南省科技创新团队（2021RC4064）。 |
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| DNA methylation profile, the flowing melody of life: Marking the 70th anniversary of discovering DNA double helix |
| LIAO Duanfang,ZHANG Jia,LU Guangming,LI Kai |
| (National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;General Hospital of Eastern Theater Command, Jinling Hospital of Nanjing University, Nanjing, Jiangsu 210016, China) |
| Abstract: |
| Seven decades ago, the discovery of double helix structure announced the genetic era of human beings; at the beginning of the century, human genomic sequencing, study of transcriptome, proteome, and epigenetics marked the post-genomic era; in recent years, the study of DNA methylation signifies the era of mysterious epigenetics. DNA methylation profile is composed of numerous DNA methylation markers in human blood. As the integrated parameter, it resembles the flowing melody of life, and reflects the physiological or pathological statues of the cells. The methylation profile can diagnose diseases such as cancer at its early stage, evaluate healthy status and constitution, classify the patterns of Chinese medicine, and standardize the diagnosis of Chinese medicine. In addition, it can help trace, identify and improve the Chinese medicines. To mark the 70th anniversary of discovering double helix structure, this paper introduces the biomedical significance of methylation profile. |
| Key words: DNA methylation methylation profile circulating cell-free DNA epigenetic early detection of cancer |
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