| 引用本文: |
李琳,曾逸笛,叶家豪,胡志希.基于益气养阴法探讨参麦注射液调控肠道菌群-TMAO-炎症轴防治慢性心力衰竭的思路与策略[J].湖南中医药大学学报,2023,43(7):1258-1262[点击复制] |
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| 基于益气养阴法探讨参麦注射液调控肠道菌群-TMAO-炎症轴防治慢性心力衰竭的思路与策略 |
| 李琳,曾逸笛,叶家豪,胡志希 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 中医学将慢性心力衰竭（chronic heart failure，CHF）归属于“胸痹”“心悸”“水肿”“喘证”等范畴。气虚证、阴虚证贯穿CHF缓解阶段的始终，气阴两虚证为常见证型，益气养阴法为治疗CHF的重要方法之一。CHF的病情进展中，肠道菌群多样性的改变与炎症标志物相关，氧化三甲胺（trimethylamine N-oxide，TMAO）是炎症反应的关键调控因子，肠道菌群-TMAO-炎症轴可能是CHF发病的关键病理机制。因此，基于以上理论及研究基础，提出参麦注射液通过益气养阴法调控肠道菌群-TMAO-炎症轴，进而改善CHF心功能的研究假说。将中医学与微生态学相结合，对于阐释益气养阴法的作用机制具有重要的科学意义，从肠道微生态角度揭示益气养阴法的作用机制，以分子生物学语言描述“益气养阴”这一中医药治法，为益气养阴法防治CHF的深入研究提出新的思路和策略。 |
| 关键词: 慢性心力衰竭 益气养阴 肠道菌群 氧化三甲胺 炎症 肠道菌群-TMAO-炎症轴 肠道假说 参脉注射液 |
| DOI：10.3969/j.issn.1674-070X.2023.07.016 |
| 投稿时间：2022-11-21 |
| 基金项目:国家自然科学基金项目（82274412）；湖南省自然科学基金项目（2023JJ30453）；长沙市自然科学基金项目（kq2208185）。 |
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| Regulating intestinal flora-TMAO-inflammation axis by Shenmai Injection to prevent and treat chronic heart failure based on tonifying qi and nourishing yin |
| LI Lin,ZENG Yidi,YE Jiahao,HU Zhixi |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Chronic heart failure (CHF) is classified as "chest impediment" "palpitations" "oedema" "dyspnoea", and other categories in Chinese medicine. Qi deficiency and yin deficiency run through the remission of CHF. Since qi and yin deficiency pattern is common, tonifying qi and nourishing yin is one of the important ways to treat CHF. In the progress of CHF, changes in intestinal flora diversity are related to inflammatory markers, and trimethylamine N-oxide (TMAO) is a key regulatory factor of inflammatory response. The intestinal flora-TMAO-inflammation axis may be the key pathological mechanism of CHF. Therefore, based on the above theories and research basis, we proposed a hypothesis that Shenmai Injection could regulate the intestinal flora-TMAO-inflammation axis by tonifying qi and nourishing yin, thus improving the cardiac function for chronic CHF patients. The integration of Chinese medicine and microecology is of scientific significance to interpreting the mechanism of action for tonifying qi and nourishing yin. The study revealed the mechanism of action for this treatment method of Chinese medicine from the perspective of intestinal microecology, and described it in the language of molecular biology, which put forward new ideas and strategies for the in-depth study of tonifying qi and nourishing yin to prevent and treat CHF. |
| Key words: chronic heart failure tonifying qi and nourishing yin intestinal flora trimethylamine N-oxide inflammation intestinal flora-TMAO-inflammation axis intestinal hypothesis Shenmai Injection |
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