| 引用本文: |
林鹏,徐易琳,周莉莉,布买热木·艾合买提,木克热木·克派吐拉,夏新华.复方连参抗炎栓的提取与干燥工艺研究[J].湖南中医药大学学报,2023,43(7):1232-1239[点击复制] |
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| 复方连参抗炎栓的提取与干燥工艺研究 |
| 林鹏,徐易琳,周莉莉,布买热木·艾合买提,木克热木·克派吐拉,夏新华 |
| (湖南中医药大学药学院, 湖南 长沙 410208;吐鲁番市维吾尔医医院, 新疆 吐鲁番市 838000) |
| 摘要: |
| 目的 优选复方连参抗炎栓的最佳水提工艺与干燥工艺参数。方法 以水提方式、浸泡时间、加水量、煎煮时间为考察因素，选择水提液中盐酸小檗碱、没食子酸转移率及浸膏得率为综合评价指标，采用信息熵-正交试验设计优化该制剂中黄连、苦参、玫瑰花、没食子的提取方式及其工艺条件，并考察其最佳干燥温度。结果 黄连与苦参、玫瑰花与没食子分别提取更有利于有效成分的浸出。黄连、苦参水提液中盐酸小檗碱提取转移率约为44%，没食子、玫瑰花水提液中没食子酸的提取转移率达84%。水提与干燥工艺的最佳条件为：黄连、苦参分别用10倍、8倍量水提取2次，提取时间分别为2.5、2.0 h，提取液经浓缩后于70℃减压干燥；没食子、玫瑰花分别用8倍、6倍量水提取两次，提取时间分别为2.5、2.0 h，提取液浓缩后于80℃减压干燥。结论 该研究结果可为确定复方连参抗炎栓合理的制备工艺提供实验依据。 |
| 关键词: 复方连参抗炎栓 正交试验 信息熵 提取工艺 干燥工艺 盐酸小檗碱 没食子酸 |
| DOI：10.3969/j.issn.1674-070X.2023.07.012 |
| 投稿时间：2023-01-06 |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2020D01A19）；湖南中医药大学研究生创新课题（2022CX82）。 |
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| Extraction and drying process of Compound Lianshen Kangyan Suppository |
| LIN Peng,XU Yilin,ZHOU Lili,Bumaryam Ahmat,Mukaram Kipaytul,XIA Xinhua |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Turpan Uygur Medical Hospital, Turpan, Xinjiang 838000, China) |
| Abstract: |
| Objective To determine the parameters of the optimal water extraction and drying process of Compound Lianshen Kangyan Suppository. Methods Factors including the method of water extraction, soaking time, the amount of water added and decocting time were investigated, transfer rates and extraction yield of berberine hydrochloride and gallic acid were set as evaluation indicators, and information entropy-orthogonal test was used to optimize the extraction methods and process conditions of Huanglian (Coptidis Rhizoma), Kushen (Sophorae Flavescentis Radix), Meiguihua (Rosae Rugosae Flos), and Moshizi (Galla Infectoriae) in the preparation. In addition, the optimal drying temperature of their water extracts was determined. Results The way of extracting Huanglian (Coptidis Rhizoma) and Kushen (Sophorae Flavescentis Radix) together, and extracting Meiguihua (Rosae Rugosae Flos) and Moshizi (Galla Infectoriae) together was more favorable for the yield of active ingredients. The transfer rate of berberine hydrochloride in the water extract of Huanglian (Coptidis Rhizoma) and Kushen (Sophorae Flavescentis Radix) was about 44%, and the transfer rate of gallic acid in the water extract of Moshizi (Galla Infectoriae) and Meiguihua (Rosae Rugosae Flos) was up to 84%. The optimal conditions of water extraction and drying process were as follows:Huanglian (Coptidis Rhizoma) and Kushen (Sophorae Flavescentis Radix) were extracted twice with 10 and 8 times of water for 2.5 h and 2.0 h respectively, and the obtained extract was concentrated and dried under the reduced pressure at 70℃; Moshizi (Galla Infectoriae) and Meiguihua (Rosae Rugosae Flos) were extracted twice with 8 and 6 times of water for 2.5 h and 2.0 h respectively, and the obtained extract was concentrated and dried under the reduced pressure at 80℃. Conclusion The results can provide experimental basis for determining the reasonable preparation technology of Compound Lianshen Kangyan Suppository. |
| Key words: Compound Lianshen Kangyan Suppository orthogonal test information entropy extraction process drying process berberine hydrochloride gallic acid |
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