| 引用本文: |
陈宇霞,张书萌,肖清玄,罗佳敏,陈杏,王萍,陈伶利,李杰.冠心病病证结合动物模型研究探讨[J].湖南中医药大学学报,2023,43(6):1144-1148[点击复制] |
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| 冠心病病证结合动物模型研究探讨 |
| 陈宇霞,张书萌,肖清玄,罗佳敏,陈杏,王萍,陈伶利,李杰 |
| (湖南中医药大学, 湖南 长沙 410208;湖南省常德市武陵区疾病预防控制中心, 湖南 常德 415000) |
| 摘要: |
| 近年来冠心病的流行率、死亡率呈逐年上升趋势，中医药治疗冠心病的疗效显著，其优势在于分证论治。融合现代医学疾病概念与中医证候特点的病证结合动物模型，是中医药研究的基础和重要组成部分。目前，制备冠心病病证结合动物模型主要采用的是在西医疾病模型上建立中医“证型”的方法，其中又以药物联合中医病因致病、手术联合中医病因致病、手术联合药物致病3种方式最为常见，少部分则应用了基因缺陷鼠。现通过梳理相关文献，对常用的冠心病病证结合动物模型制备方法进行阐述，分析其特点，以期为中医药防治冠心病研究提供参考和依据。 |
| 关键词: 冠心病|病证结合|动物模型|病因病机|中西医结合 |
| DOI：10.3969/j.issn.1674－070X.２０23.06.030 |
| 投稿时间：2022-11-22 |
| 基金项目:国家自然科学基金项目（81874375）；湖南省自然科学基金项目（2022JJ30430）；湖南省中医药科研计划重点项目（2021024）；湖南省教育厅科学研究重点项目（21A0231，22A0278)；湖南中医药大学校级科研重点项目（2020XJJJ002）；湖南中医药大学研究生创新课题（2021CX45）。 |
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| Animal models for integrated differentiation of coronary heart disease and pattern |
| CHEN Yuxia,ZHANG Shumeng,XIAO Qingxuan,LUO Jiamin,CHEN Xing,WANG Ping,CHEN Lingli,LI Jie |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Changde Wuling District Center for Disease Control and Prevention, Changde, Hunan 415000, China) |
| Abstract: |
| In recent years, the prevalence and mortality of coronary heart disease have been increasing constantly. Chinese medicine is remarkably effective in treating coronary heart disease, with its advantage of treatment based on pattern differentiation. And the animal modeling for integrated differentiation of disease and pattern, integrating the concept of modern medical diseases with TCM pattern characteristics, is the foundation and an important part of TCM research. At present, the animal models for integrated differentiation of coronary heart disease and pattern are mainly prepared by establishing TCM pattern on the basis of western medicine disease model. Among them, drugs combined with TCM etiology, surgery combined with TCM etiology, and surgery combined with drugs are the most common ways, and a few models were established using genetically defective rats. By combing relevant literature, this paper expounds commonly used methods for preparing animal models for integrated differentiation of coronary heart disease and pattern, and analyzes their characteristics, so as to provide reference and basis for TCM prevention and treatment of coronary heart disease. |
| Key words: coronary heart disease|integrated differentiation of disease and pattern|animal models|etiology and pathogenesis|integration of Chinese and western medicine |
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