| 引用本文: |
孙文,肖江,郑欣宇,周绍明,杨萍.川金解郁汤干预轻中度抑郁患者的疗效分析及代谢组学研究[J].湖南中医药大学学报,2023,43(5):940-948[点击复制] |
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| 川金解郁汤干预轻中度抑郁患者的疗效分析及代谢组学研究 |
| 孙文,肖江,郑欣宇,周绍明,杨萍 |
| (湖南省脑科医院精神科, 湖南 长沙 410007;湖南中医药大学临床医学院, 湖南 长沙 410208) |
| 摘要: |
| 目的 分析川金解郁汤(Chuanjin Jieyu Decoction, CJJYD)对轻中度抑郁(mild to moderate depression, MTMD)患者干预前后的代谢物差异性及相关代谢物变化规律,为CJJYD治疗MTMD提供科学依据。方法 纳入湖南省脑科医院2020年1月至12月期间23名MTMD患者作为病例组(Dep组)、健康人21名作为对照组(CT组),Dep组予以CJJYD干预6周,早晚各服1剂,每次100 mL。采用汉密尔顿抑郁量表(Hamilton depression scale, HAMD)和抑郁自评量表(self-rating depression scale, SDS)评定疗效;超高效液相色谱-高分辨质谱联用技术分析干预前后血浆代谢物变化;采用多维度统计分析,筛选差异代谢物并进行分析。结果 MTMD患者经CJJYD干预后,HAMD和SDS评分明显降低(P<0.01)。与CT组相比,Dep组患者血浆中检测145个差异代谢物,涉及亚油酸代谢等38条代谢通路;Dep组经CJJYD干预后,患者血浆中检测46个差异代谢物,涉及烟酸和烟酰胺代谢等11条代谢通路。结论 MTMD患者经CJJYD干预后,抑郁症状得到改善,代谢组学有差异性代谢物,涉及亚油酸代谢、烟酸和烟酰胺代谢、精氨酸和脯氨酸代谢等代谢通路,可能为其抗抑郁的机制之一。 |
| 关键词: 抑郁症 川金解郁汤 超高效液相色谱-高分辨质谱 差异代谢物 郁金 川芎 |
| DOI：10.3969/j.issn.1674-070X.2023.05.028 |
| 投稿时间：2023-02-11 |
| 基金项目:湖南省卫生健康委员会科研课题（202103090662，202203094023）；湖南省临床医学研究中心项目（2021SK4022）；湖南省重点研发项目（2020SK2123）。 |
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| Clinical efficacy and metabolomics of Chuanjin Jieyu Decoction in treating mild to moderate depression |
| SUN Wen,XIAO Jiang,ZHENG Xinyu,ZHOU Shaoming,YANG Ping |
| (Department of Psychiatry, Hunan Brain Hospital, Changsha, Hunan 410007, China;School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To analyze differential metabolites and the associated metabolite change rules of Chuanjin Jieyu Decoction (CJJYD) in treating mild to moderate depression (MTMD) both before and after intervention, and to provide scientific bases for treating MTMD patients with CJJYD. Methods A total of 23 MTMD patients received in Hunan Brain Hospital from January to December 2020 were included as case group (Dep group). In addition, 21 healthy people were set as the control group (CT group). Dep group was treated with CJJYD for 6 weeks, with 1 dose of 100 mL in the morning and the same dose in the evening. The Hamilton depression scale (HAMD) and self-rating depression scale (SDS) were used to assess the efficacy, and ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC-MS) was taken to analyze the changes in plasma metabolites before and after treatment. Differential metabolites were screened and analyzed using mutil-dimensional statistical analysis. Results MTMD patients showed a significant lower HAMD and SDS scores after being treated with CJJYD (P<0.01). A total of 145 differential metabolites were detected in the plasma of Dep group compared to CT group, involving 38 metabolic pathways such as linoleic acid metabolism; 46 differential metabolites were identified in the plasma of Dep group after CJJYD intervention, involving 11 metabolic pathways such as niacin and nicotinamide metabolism. Conclusion Depression symptoms were alleviated in MTMD patients after CJJYD treatment. Differential metabolites were shown in metabolomics after CJJYT intervention, involving metabolic pathways such as linoleic acid metabolism, niacin and nicotinamide metabolism, and arginine and proline metabolism, which may be one of its anti-depression mechanisms. |
| Key words: depression Chuanjin Jieyu Decoction ultra-high performance liquid chromatography-high resolution mass spectrometry differential metabolites Yujin (Radix Curcumae) Chuanxiong (Rhizoma Chuanxiong) |
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