| 引用本文: |
张林坤,陈英华,孙玮,王浩宇,李俊峰,秦瑞琦,苏晓庆.醒神通络益智针法治疗血管性认知障碍的临床疗效观察[J].湖南中医药大学学报,2023,43(5):891-896[点击复制] |
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| 醒神通络益智针法治疗血管性认知障碍的临床疗效观察 |
| 张林坤,陈英华,孙玮,王浩宇,李俊峰,秦瑞琦,苏晓庆 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040) |
| 摘要: |
| 目的 观察醒神通络益智针法治疗血管性认知障碍(vascular cognitive impairment, VCI)的临床疗效。方法 选取VCI患者68例,将其随机分为观察组(34例)与对照组(34例)。观察组采用醒神通络益智针刺法治疗,对照组采用常规针刺法治疗。两组均每日治疗1次,连续治疗6 d,休息1 d后再进行下一疗程治疗,共治疗4个疗程。比较两组临床疗效以及治疗前后简易智力状态检查(mini-mental state examination, MMSE)评分、蒙特利尔认知评估量表(montreal cognitive assessment, MoCA)评分、工具性日常生活活动能力(instrumental activities of daily living, IADL)评分、总体衰退量表(global deterioration scale, GDS)评分等级、血清白细胞介素-6(interleukin-6, IL-6)及肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)水平的变化。结果 治疗后,观察组总有效率94%,优于对照组的76%(P<0.05);两组治疗后MMSE评分和MoCA评分均较治疗前明显升高(P<0.01),且观察组明显高于对照组(P<0.05);两组治疗后IADL评分、GDS等级及血清IL-6、TNF-α水平较治疗前明显降低(P<0.01),且观察组明显低于对照组(P<0.05)。结论 醒神通络益智针法治疗VCI临床疗效确切,可明显改善VCI患者的认知功能、日常生活活动能力,能有效改善相关血清炎性因子水平,为临床应用提供理论依据。 |
| 关键词: 血管性认知障碍 醒神通络益智针法 针刺 白细胞介素-6 肿瘤坏死因子-α 临床观察 |
| DOI：10.3969/j.issn.1674-070X.2023.05.019 |
| 投稿时间：2022-12-08 |
| 基金项目:国家自然科学基金项目（82074530）；黑龙江省自然科学基金项目（ZD2021H007）。 |
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| Observation of curative effects of Xingshen Tongluo Yizhi Acupuncture on vascular cognitive impairment |
| ZHANG Linkun,CHEN Yinghua,SUN Wei,WANG Haoyu,LI Junfeng,QIN Ruiqi,SU Xiaoqing |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The First Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China) |
| Abstract: |
| Objective To observe the curative effects of Xingshen Tongluo Yizhi Acupuncture in treating vascular cognitive impairment (VCI). Methods Sixty-eight VCI patients were selected and randomly divided into observation group (n=34) and control group (n=34). The observation group was treated by Xingshen Tongluo Yizhi Acupuncture, while the control group received conventional acupuncture. Both groups were treated once a day for consecutive 6 d. After 1 d off, the next course of treatment began. Totally, there were 4 courses. The curative effects of two groups were compared, the changes of two groups before and after treatment were checked, respectively in mini-mental state examination (MMSE) score, montreal cognitive assessment (MoCA) score, instrumental activities of daily living (IADL) score, global deterioration scale (GDS) score grade, and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. Results After treatment, the total effective rate of the observation group was 94%, which was better than 76% of the control group (P<0.05); the MMSE score and MoCA score of both groups were significantly higher after treatment than the scores before treatment (P<0.01), and the scores of observation group were significantly higher than those of control group (P<0.05). After treatment, the IADL score, GDS grade, and serum IL-6 and TNF-α levels of both groups were significantly lower than those before treatment (P<0.01), and these of observation group were significantly lower than those of control group (P<0.05). Conclusion The curative effects of Xingshen Tongluo Yizhi Acupuncture for VCI is definite. It can ignificantly improve the VCI patients' cognitive function and their activities of daily living. Meanwhile, Xingshen Tongluo Yizhi Acupuncture effectively elevates the level of related serum inflammatory factors, which provides a theoretical basis for clinical application. |
| Key words: vascular cognitive impairment Xingshen Tongluo Yizhi Acupuncture acupuncture interleukin-6 tumor necrosis factor-α clinical observation |
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