| 引用本文: |
吴吉,裴方妤,张涤,朱沁泉.BDNF信号通路在儿童孤独症谱系障碍中的作用机制及中医药干预研究进展[J].湖南中医药大学学报,2023,43(4):759-766[点击复制] |
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| BDNF信号通路在儿童孤独症谱系障碍中的作用机制及中医药干预研究进展 |
| 吴吉,裴方妤,张涤,朱沁泉 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 脑源性神经营养因子(brain-derived neurotrophic factor, BDNF)为细胞内信号通路转导分子，调节众多重要的生理过程。BDNF信号通路对于神经元的存活、形态发生和可塑性至关重要。目前，认为BDNF信号通路失调与孤独症谱系障碍（autism spectrum disorder, ASD）的发病机制密切相关，BDNF在外周血中的浓度可能成为评估ASD的潜在生物学指标。中医药治疗ASD具有整体调节和多通道、多靶点的优势，可能通过调控BDNF信号通路改善ASD核心症状或伴随症状。目前，研究存在的问题主要有：BDNF下游机制复杂，与ASD发病关系的相关机制未完全阐明；中医药治疗儿童ASD的报道多为中药复方的临床观察研究，尚缺乏中药活性成分疗效机制的动物实验及针对BNDF信号通路的研究。今后的研究中，需进一步设计科学严谨的实验方案，深入了解BDNF信号通路的作用机制。对BDNF信号通路在ASD发病机制中的作用及中医药研究进行综述，以期为ASD的靶向治疗提供理论依据。 |
| 关键词: 孤独症谱系障碍 脑源性神经营养因子 信号通路 中医药 靶点 儿童 |
| DOI：10.3969/j.issn.1674-070X.2023.04.030 |
| 投稿时间：2021-12-10 |
| 基金项目:湖南省科技厅重点领域研发计划项目（2019SK2081）；湖南省卫生健康委员会科研课题（202206010043）；湖南中医药大学校极研究生创新课题（2022CX157）。 |
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| Mechanisms of BDNF signaling pathway in autism spectrum disorder and research progress of Chinese medicine intervention |
| WU Ji,PEI Fangyu,ZHANG Di,ZHU Qinquan |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Brain-derived neurotrophic factor (BDNF) is an intracellular signal transduction molecule that regulates important physiological processes. Furthermore, BDNF signaling pathway is essential for neuronal survival, morphogenesis and plasticity. Since the imbalance of BDNF signaling pathway is considered to be closely related to the pathogenesis of autism spectrum disorder (ASD), the concentration of BDNF in peripheral blood may become a potential biological index to evaluate ASD. Chinese medicine treatment of ASD can regulate overally with multiple channels and multiple targets. It may improve the core or concomitant symptoms of ASD by regulating BDNF signaling pathway. The main problems in its current research are as follows: the downstream mechanism of BDNF is complex and the ASD pathogenesis is not fully elucidated．Most reports on the treatment of children with ASD by Chinese medicine are clinical observation of formulas, but there is still a lack of animal experiment on the therapeutic mechanisms of active ingredients of formula and research on BDNF signaling pathway. In the future research, it is necessary to further design a scientific and rigorous experimental scheme to deeply understand the mechanisms of BDNF signaling pathway. This paper reviews the role of BDNF signaling pathway in the pathogenesis of ASD and the research of Chinese medicine, in order to provide a theoretical basis for the targeted treatment of ASD. |
| Key words: autism spectrum disorder brain-derived neurotrophic factor signaling pathways Chinese medicine target child |
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