| 引用本文: |
黄念文,王彬,王继升,赵琦,冯隽龙,孙龙吉,李海松.论肠道菌群是补肾活血法治疗慢性前列腺炎的重要靶点[J].湖南中医药大学学报,2023,43(3):565-570[点击复制] |
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| 论肠道菌群是补肾活血法治疗慢性前列腺炎的重要靶点 |
| 黄念文,王彬,王继升,赵琦,冯隽龙,孙龙吉,李海松 |
| (北京中医药大学东直门医院) |
| 摘要: |
| 慢性前列腺炎（chronic prostatitis, CP）的病因较为复杂，随着高通量测序技术的发展，发现肠道菌群紊乱可能是CP发病的一个重要因素，故肠道菌群可作为防治CP的靶点。中医学认为肾虚血瘀为CP的核心病机，且补肾活血类中药可改善CP的临床症状，在调节肠道菌群紊乱方面亦有着独特的优势，这或许是补肾活血法有效治疗CP的科学机制之一。基于此，从肠道菌群角度出发，通过阐述肠道菌群对CP发病的影响，结合肾虚血瘀与肠道菌群的内在联系及补肾活血类中药对肠道菌群的调节作用，推测补肾活血类中药通过调节肠道菌群治疗CP的机制可能与改善异常心理情绪、抑制炎症因子释放及增加代谢产物丙酸的含量等相关。由此，提出肠道菌群为补肾活血法治疗CP的重要靶点，或可成为未来CP中药研究的新方向。 |
| 关键词: 慢性前列腺炎 肠道菌群 补肾活血 中医药 治疗靶点 |
| DOI：10.3969/j.issn.1674-070X.2023.03.028 |
| 投稿时间：2022-11-17 |
| 基金项目:中华中医药学会青年求实项目（2021-QNQS-03）；中国博士后创新人才支持计划项目（BX20220047）。 |
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| Intestinal flora is an important target to treat chronic prostatitis by tonifying the kidney and activating blood circulation |
| HUANG Nianwen,WANG Bin,WANG Jisheng,ZHAO Qi,FENG Juanlong,SUN Longji,Li Haisong |
| (Dongzhimen Hospital of Beijing University of Chinese Medicine) |
| Abstract: |
| The etiology of chronic prostatitis (CP) complex. With the development of high-throughput sequencing technology, the disorder of intestinal flora may be an important factor in the pathogenesis of CP. Therefore, the intestinal flora can be the target of CP prevention and treatment. In Chinese medicine, kidney deficiency and blood stasisit is believed to be the core pathogenesis of CP; tonifying the kidney and activating blood circulation can relieve clinical symptoms, and it has unique advantages in regulating the disorder of intestinal flora, which may be one of the scientific mechanisms for treating CP effectively by tonifying the kidney and activating blood circulation. Therefore, from the perspective of intestinal flora, the effects of intestinal flora on the pathogenesis has been elaborated, the regulatory effect of Chinese medicine for tonifying the kidney and activating blood circulation on intestinal flora has been discussed based on the internal relationship between kidney deficiency and blood stasis. This paper speculates that Chinese medicine tonifies the kidney and activates blood circulation to treat CP by regulating intestinal flora and the mechanism may be related to improving abnormal psychological mood, inhibiting the release of inflammatory factors, and increasing the metabolite content of propionic acid. Therefore, intestinal flora is an important target for CP by invigorating the kidney and activating blood circulation, and it may be the new direction for studying the treatment of CP with Chinese medicine in the future. |
| Key words: chronic prostatitis intestinal flora tonifying the kidney and activating blood circulation Chinese medicine treatment target |
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