| 引用本文: |
米惠,孙克伟,李菁,彭憬,伍玉南,袁维.基于数据挖掘分析孙克伟教授治疗代偿期乙肝肝硬化的用药规律[J].湖南中医药大学学报,2023,43(2):310-316[点击复制] |
|
| |
|
|
| 本文已被：浏览 3235次 下载 1241次 |
| 基于数据挖掘分析孙克伟教授治疗代偿期乙肝肝硬化的用药规律 |
| 米惠,孙克伟,李菁,彭憬,伍玉南,袁维 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 运用数据挖掘技术探讨孙克伟教授治疗代偿期乙肝肝硬化的用药规律，为临床治疗提供借鉴。方法 收集整理2021年4月1日至2022年4月1日孙克伟教授中医药治疗代偿期乙肝肝硬化患者的临床资料，建立代偿期乙肝肝硬化病案数据库，对符合标准病例的中药分别进行频次统计及性味、归经、功效分类、关联规则以及聚类分析。结果 纳入病案131例，涉及77味中药（累计频次1319次），统计分析得到甘草、柴胡、白术、黄芪等频数大于20的中药16味。对所有中药的性味、归经及功效分类进行统计分析：药性以温、寒、平为主，药味以甘、苦、辛为主，归经以脾、肺、肝、胃经为主，功效分类以补虚药、解表药、清热药、利水渗湿药为主；对中药进行相关性分析：提取得到2味药物组成的药物组合21个，3味强关联药物组合17个；聚类分析得到4类药物组合。结论 孙克伟教授治疗代偿期乙肝肝硬化以疏肝健脾、清热利湿、活血化瘀为主，同时辨证应用解表、利水渗湿等祛邪之品，寓攻于补，攻补兼施，扶正祛邪贯穿始终。 |
| 关键词: 代偿期乙肝肝硬化 积聚 孙克伟 名医经验 数据挖掘 用药规律 |
| DOI：10.3969/j.issn.1674-070X.2023.02.022 |
| 投稿时间：2022-09-27 |
| 基金项目:国家自然科学基金青年基金项目（81904182）；湖南省自然科学基金项目（2020JJ5441）；湖南省卫生健康委员会科研计划课题项目（20200752）。 |
|
| Medication rules of Professor SUN Kewei in treating compensatory hepatitis B cirrhosis based on data mining |
| MI Hui,SUN Kewei,LI Jing,PENG Jing,WU Yunan,YUAN Wei |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To discuss the medication rules of Professor SUN Kewei in treating compensated hepatitis B cirrhosis by data mining, so as to provide reference for clinical treatment. Methods The clinical cases of compensated hepatitis B cirrhosis treated by Professor SUN Kewei with Chinese medicine from April 1, 2021 to April 1, 2022 were collected and sorted out, and the case database was then established. As to the Chinese medicines meeting the standard cases, the frequency, property and taste, channel tropism, and efficacy were classified, and the association rules and cluster analysis were conducted. Results A total of 131 medical cases were included, involving 77 kinds of Chinese medicines (with the cumulative frequency of 1319 times). Sixteen Chinese medicines with the frequency higher than 20, such as Gancao (Licorice Root), Chaihu (Chinese Thorowax Root), Baizhu (White Atractylodes Rhizome), and Huangqi (Milkvetch Root), were statistically analyzed on their properties and tastes, channel tropism and efficacy classification. The properties are mainly warm, cold and flat; the tastes are mostly sweet, bitter and pungent; the medicines mainly access to the spleen, lung, liver and stomach channels; the medicines are mainly tonic, exterior-releasing, interior heat-clearing, urination-promoting, and dampness-draining. Twenty one drug combinations composed of two drugs and 17 drug combinations with three strong-correlated drugs were extracted by correlation analysis; four drug combinations were obtained by cluster analysis. Conclusion Professor SUN Kewei treats compensated hepatitis B cirrhosis mainly by soothing the liver and strengthening the spleen, clearing away heat and draining dampness, and promoting blood circulation and removing blood stasis. Furthermore, he dialectically takes the drugs relieving exterior syndrome, promoting diuresis and eliminating dampness to eliminate pathogens. In conclusion, he uses attack to supplement, combines attack with supplement, and reinforces healthy qi to eliminate pathogenic factors in the whole treating process. |
| Key words: compensatory hepatitis B cirrhosis accumulation SUN Kewei famous doctor's experience data mining medication rules |
|
二维码（扫一下试试看！） |
|
|
|
|
