| 引用本文: |
吴伊莹,柳玉佳,廖亮英,郭志华.基于数据挖掘的旷惠桃教授治疗类风湿关节炎的方药规律研究[J].湖南中医药大学学报,2023,43(1):88-94[点击复制] |
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| 基于数据挖掘的旷惠桃教授治疗类风湿关节炎的方药规律研究 |
| 吴伊莹,柳玉佳,廖亮英,郭志华 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 通过数据挖掘技术，分析旷惠桃教授治疗类风湿关节炎（rheumatoid arthritis,RA）的临床经验。方法 采集2020年1月1日至2021年12月1日旷惠桃教授治疗RA的医案，录入中医传承计算平台V3.0系统，采用软件中的关联规则、聚类分析等数据挖掘方法，探析旷惠桃教授治疗RA医案中的常见症状、药物频次及关联规律。结果 纳入237名RA患者，对436则处方进行分析发现，RA常见症状为关节疼痛肿胀、活动不利、畏寒恶风；治疗RA常用药物为当归、黄芪、桂枝、牛膝、白芍等；以苦味中药、归肝经中药居多；常用活血化瘀类、补虚类、祛风湿类中药；发掘出常用药对与组合、核心基础方、6个核心类方。结论 真实世界数据验证了旷惠桃教授“温养治痹”的学术思想，治疗以温养气血为根本，祛风除痹并重，再根据临床寒热虚实进行灵活加减，疾病各期均重视顾护阳气，以善用虫类药为用药特色。 |
| 关键词: 类风湿关节炎 尪痹 数据挖掘 温养治痹 旷惠桃 |
| DOI：10.3969/j.issn.1674-070X.2023.01.013 |
| 投稿时间：2022-02-16 |
| 基金项目:旷惠桃全国名老中医药专家传承工作室建设项目（国中医药人教发〔2014〕20号）；湖南省卫生健康委员会科研项目（202103101094，20201816）；湖南中医药大学中西医结合一流学科基金项目（2020ZXYJH15）；湖南中医药大学校级科研基金项目（2018XJJJ38）。 |
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| Medication rules of Professor KUANG Huitao in treating rheumatoid arthritis based on data mining |
| WU Yiying,LIU Yujia,LIAO Liangying,GUO Zhihua |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To analyze Professor KUANG Huitao's clinical experience in treating rheumatoid arthritis (RA) based on data mining. Methods The medical cases of Professor KUANG Huitao in treating RA from January 1, 2020 to December 1, 2021 were collected and entered into the TCM inheritance computing platform (V3.0). Data mining methods such as association rules and cluster analysis in the software were used to explore the common symptoms, drug frequencies and association rules. Results By analyzing the data of 237 patients with RA and 436 prescriptions, we have identified the following medication rules. The common symptoms of RA were joint pain and swelling, poor movement, and cold and wind intolerance; the common drugs for RA include Danggui (Radix Angelicae Sinensis), Huangqi (Radix Astragali Seu Hedysari), Guizhi (Ramulus Cinnamomi), Niuxi (Radix Achyranthis Bidentatae), Baishao (Radix Paeoniae Alba); the prescribed medicines were mainly bitter and accessing the liver meridian; the commonly used medicines mainly function to circulate blood circulation and transform stasis, tonify deficiency, and dispel wind and dampness; the commonly used drug pairs and combinations, core basic formulas, and 6 core formulas were identified. Conclusion Professor KUANG's academic thought of "warming and nourishing to treat bi-impediment" is verified by the real data. She warms and nourishes qi and blood, pays equal attention to dispelling wind and eliminating bi-impediment, and then flexibly makes modifications based on cold-heat-deficiency-excess. Her treatment is characterized by the emphasis on warming yang in each stage of the disease and making good use of insect medicines. |
| Key words: rheumatoid arthritis wang bi (rheumatoid arthritis) data mining warm and nourish to treat bi-impediment KUANG Huitao |
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