| 引用本文: |
赵会,朱艳.基于TRPV1离子通道探讨艾灸镇痛机制[J].湖南中医药大学学报,2022,42(12):2117-2121[点击复制] |
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| 基于TRPV1离子通道探讨艾灸镇痛机制 |
| 赵会,朱艳 |
| (安徽中医药大学研究生院, 安徽 合肥 230000;安徽省针灸医院老年病一科, 安徽 合肥 230061) |
| 摘要: |
| 瞬时感受器电位香草酸受体1(transient receptor potential vanilloid 1, TRPV1)作为非选择性阳离子通道和温痛觉感受器,可由辣椒素、内源性炎症介质(如缓激肽、胰蛋白酶等)和外源性有害刺激(如冷、热、刺激性化合物)、内环境酸碱度和局部电压等激活,并能介导炎性痛和神经病理性疼痛,是产生痛觉过敏的关键离子通道。大量研究已证实,TRPV1是艾灸发挥镇痛作用的关键。本文以TRPV1为切入点深入探讨艾灸镇痛的可能机制,以期为临床治疗提供理论依据。 |
| 关键词: 瞬时感受器电位香草酸受体1 艾灸 镇痛 腧穴热敏化 机制探讨 |
| DOI：10.3969/j.issn.1674-070X.2022.12.027 |
| 投稿时间：2022-07-25 |
| 基金项目:国家自然科学基金项目(81403484); 安徽省高校自然科学基金项目(KJ2019A0448); 安徽省中医药传承创新科研项目(2020ccyb13); 安徽中医药大学临床科研项目(2021efyic05) |
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| Discussing analgesic mechanism of moxibustion based on TRPV1 ion channel |
| ZHAO Hui,ZHU Yan |
| (Graduate School of Anhui University of Chinese Medicine, Hefei, Anhui 230000, China;The First Department of Geriatrics, Anhui Acupuncture Hospital, Anhui 230061, China) |
| Abstract: |
| Transient receptor potential vanilloid 1(TRPV1) is a non-selective cation channel and a warm pain receptor. It can be activated by capsaicin, endogenous inflammatory mediators(such as bradykinin and trypsin) and exogenous harmful stimuli(such as cold, heat and irritating compounds), pH of internal environmental and local voltage, and it can mediate inflammatory pain and neuropathic pain and functions as the key ion channel for hyperalgesia. Since a large number of studies have confirmed that TRPV1 played the key role in analgesic effect of moxibustion, this paper discussed the possible mechanism of moxibustion analgesia with TRPV1 as the starting point, in order to provide a theoretical basis for clinical treatment. |
| Key words: transient receptor potential vanilloid 1 moxibustion analgesia acupoint heat sensitization mechanism discussion |
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