| 引用本文: |
彭喜洋,王月爱,陈晓琼,罗佳,李苏,欧晓霞,梁黎昕.瓜蒌薤白半夏汤对冠心病痰浊痹阻证患者室壁运动幅度的影响[J].湖南中医药大学学报,2022,42(9):1523-1529[点击复制] |
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| 瓜蒌薤白半夏汤对冠心病痰浊痹阻证患者室壁运动幅度的影响 |
| 彭喜洋,王月爱,陈晓琼,罗佳,李苏,欧晓霞,梁黎昕 |
| (湖南中医药大学第一附属医院超声影像科, 湖南 长沙 410007;湖南中医药大学第一附属医院中医内科, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察瓜蒌薤白半夏汤加减对冠心病痰浊痹阻证患者室壁运动幅度的影响。方法 选取2020年5月至2021年5月在湖南中医药大学第一附属医院住院的冠心病痰浊痹阻证患者60例。采用随机数字表法分为观察组和对照组，每组30例。对照组患者采用常规西药实施治疗，观察组在对照组西药治疗的基础上加用瓜蒌薤白半夏汤加减治疗。对比分析两组左心室短轴切面12节段M型超声室壁运动幅度参数变化、血脂变化、中医证候要素积分变化、心电图疗效及临床疗效。结果 与治疗前比较，观察组治疗后各节段M型超声心动图室壁运动幅度均显著增高（P＜0.05），中医证候要素积分显著降低（P＜0.05），心电图及临床症状显著改善（P＜0.05），且观察组改善情况均优于对照组(P＜0.05)；观察组治疗后总胆固醇（total cholesterol,TC）、甘油三酯（triglyceride,TG）、低密度脂蛋白（low-density lipoprotein cholesterol,LDL-C）显著降低（P＜0.05），高密度脂蛋白（high-density lipoprotein cholesterol,HDL-C）显著升高（P＜0.05），且观察组TC、TG、LDL-C、HDL-C改善情况均优于对照组（P＜0.05）。结论 瓜蒌薤白半夏汤加减能显著改善冠心病痰浊痹阻证患者血脂水平、心电图及临床症状，且可以不同程度地提高其室壁运动幅度，从而提高心功能。 |
| 关键词: 瓜蒌薤白半夏汤 冠心病 痰浊痹阻证 室壁运动幅度 解剖M型超声心动图 |
| DOI：10.3969/j.issn.1674-070X.2022.09.017 |
| 投稿时间：2021-11-05 |
| 基金项目:湖南省卫生健康委员会科研基金项目(20201300),湖南中医药大学校级科研基金项目(ZYYDX201744)。 |
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| Effects of Gualou Xiebai Banxia Decoction on the amplitude of ventricular wall mmotion in patients with coronary heart disease of phlegm-turbid obstruction syndrome |
| PENG Xiyang,WANG Yueai,CHEN Xiaoqiong,LUO Jia,LI Su,OU Xiaoxia,LIANG Lixin |
| (Department of Ultrasound Imaging, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Department of Traditional Chinese Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the effects of modified Gualou Xiebai Banxia Decoction on the amplitude of ventricular wall motion in patients with coronary heart disease of phlegm-turbid obstruction syndrome. Methods A total of 60 patients with coronary heart disease of phlegm-turbid obstruction syndrome were hospitalized in the First Hospital of Hunan University of Chinese Medicine from May 2020 to May 2021. The patients were randomly divided into observation group (n=30) and control group (n=30) by random number table method. The patients in the control group were treated with western medicine, and the observation group were treated with the modified Gualou Xiebai Banxia Decoction on the basis of western medicine used in the control group. The 12-segment M-mode ultrasound ventricular wall motion amplitude parameters, blood lipid, traditional Chinese medicine (TCM) syndrome scores, electrocardiographic efficacy and clinical efficacy between the two groups were compared and analyzed. Results Compared with the condition before treatment, after treatment, the ventricular wall motion amplitude of M-mode echocardiography in each segment of the two groups increased significantly (P<0.05); the TCM syndrome scores decreased significantly (P<0.05); the electrocardiogram and clinical symptoms were significantly improved (P<0.05); the improvement in the observation group was better than that in the control group (P<0.05). After treatment, the total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) decreased significantly (P<0.05); the high-density lipoprotein cholesterol (HDL-C) increased significantly (P<0.05) in the observation group; the improvement of TC, TG, LDL-C and HDL-C in the observation group were better than those in the control group (P<0.05). Conclusion Modified Gualou Xiebai Banxia Decoction can significantly improve the blood lipid level, electrocardiographic and clinical symptoms of patients of coronary heart disease with phlegm-turbid obstruction syndrome, and comprehensively increase the amplitude of ventricular wall motion in different degrees, so as to improve cardiac function. |
| Key words: Gualou Xiebai Banxia Decoction coronary heart disease phlegm-turbid obstruction syndrome ventricular wall motion amplitude anatomical M-mode echocardiography |
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