| 引用本文: |
张柏雯,邹伟.线粒体自噬在脑出血中的神经保护机制研究概述[J].湖南中医药大学学报,2022,42(5):854-861[点击复制] |
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| 线粒体自噬在脑出血中的神经保护机制研究概述 |
| 张柏雯,邹伟 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040) |
| 摘要: |
| 线粒体自噬发生于脑出血原发性损伤和继发性损伤中，并与脑出血后受损脑组织周围发生的多种生物学效应密切相关，因此探究线粒体自噬对脑出血神经保护机制至关重要。由于脑内微环境在病理状态下的变化，导致多种细胞状态如炎症、凋亡、自噬等发生并对脑神经产生一定的影响，故本文基于线粒体自噬与细胞炎症、凋亡、铁死亡在脑出血继发性损伤中的相互作用关系，探讨线粒体自噬对脑出血后脑组织的神经保护作用。 |
| 关键词: 脑出血 神经保护机制 线粒体自噬 凋亡 炎症 铁死亡 |
| DOI：10.3969/j.issn.1674-070X.2022.05.028 |
| 投稿时间：2021-07-06 |
| 基金项目:国家自然科学基金面上项目（82074540）。 |
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| Overview of neuroprotective mechanism of mitochondrial autophagy in intracerebral hemorrhage |
| ZHANG Baiwen,ZOU Wei |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China) |
| Abstract: |
| Mitochondrial autophagy occurs in primary and secondary injury of intracerebral hemorrhage (ICH), which is closely related to many biological effects around damaged brain tissue after ICH, so it is very important to explore its neuroprotective mechanism of mitochondrial autophagy in ICH. Due to the changes of brain microenvironment in pathological state, a variety of cell states such as inflammation, apoptosis, and autophagy occur as well as have a certain impact on the brain nerve. Based on the interaction between mitochondrial autophagy and cell inflammation, apoptosis, ferroptosis in the secondary injury of ICH, this study explores the neuroprotective effect of mitochondrial autophagy on brain tissue after ICH. |
| Key words: intracerebral hemorrhage neuroprotective mechanism mitochondrial autophagy apoptosis inflammation ferroptosis |
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