| 引用本文: |
邓凯文,贺琪珺,李海英,王敏存,周燕子,陈定芳,贺福元.回眸中医药超分子化学研究十载，构筑中医药超分子“气析”理论[J].湖南中医药大学学报,2022,42(3):477-485[点击复制] |
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| 回眸中医药超分子化学研究十载，构筑中医药超分子“气析”理论 |
| 邓凯文,贺琪珺,李海英,王敏存,周燕子,陈定芳,贺福元 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学中医药超分子机理与数理特征化实验室, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学中医药超分子机理与数理特征化实验室, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学药学院, 湖南 长沙 410208;湖南中医药大学中药炮制与制剂制备工程技术实验室, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学中医药超分子机理与数理特征化实验室, 湖南 长沙 410208;湖南中医药大学药学院, 湖南 长沙 410208;湖南中医药大学中药炮制与制剂制备工程技术实验室, 湖南 长沙 410208;中药药性与药效国家中医药管理局重点实验室, 湖南 长沙 410208) |
| 摘要: |
| 回眸中医药超分子化学研究历程，梳理和阐明怎样由中医药理论现代化所面临的问题推论出中医药超分子化学的破解之策，由此建立中医药超分子“气析”理论，找准现代化研究方法学大门。置自然界生物演化的大背景中来考虑，中医药理论是古代医家对生命体微观物质运行规律的宏观总结，本质上是对人体与自然界“分子社会”信息交流管控规律的揭示，常采用人文社会科学语言来表述医学科学的运行规律，具人文自然交融特质，是最典型的交叉学科。若要破解，就必须从现代自然科学中去寻觅既具有人文社会自然交融属性，又能反映生命体本质演化规律的学科，这便是生物超分子化学。为此，本团队于2011年展开了中医药理论、经络、药性、药理、品种归属、炮制、药剂、质量等超分子化学研究，完整提出了中医药学科发展面临的3个重大科学前沿问题和3个重大工程技术难题的破解之策，继而总结形成了现代化的中医药超分子“气析”理论诠释体系。 |
| 关键词: 中医药 基础理论 超分子化学 气析 科学前沿问题 工程技术难题 中医药现代化 方法学 |
| DOI：10.3969/j.issn.1674-070X.2022.03.024 |
| 投稿时间：2021-02-04 |
| 基金项目:国家自然科学基金项目（81573691,81874507,81903759）；湖南省教育厅创新平台开放基金项目（18K071）；长沙市科技计划项目（kq1907137,kq2004059）；湖南省大学生创新创业训练计划项目（S202010541043）。 |
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| Review of the TCM supramolecular chemistry research for 10 years and construct TCM supramolecular “Qi chromatography” theory |
| DENG Kaiwen,HE Qijun,LI Haiying,WANG Mincun,ZHOU Yanzi,CHEN Dingfang,HE Fuyuan |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Piece Processing and Pharmaceutical Preparation Engineering Technological Laboratory of TCM, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Piece Processing and Pharmaceutical Preparation Engineering Technological Laboratory of TCM, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Property and Pharmacodaynamic Key Laboratory of TCM, State Administration of Traditional Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| This paper systematically reviews the course of traditional Chinese medicine (TCM) supramolecular chemistry research, to comb and clarify how to deduce the solution that is found TCM supramolecular chemistry from the problems faced by the modernization of TCM theory, so as to establish TCM supramolecular "Qi chromatography" theory, which will consequently found as the correct door opened to the research methodology for the systematical modernization of TCM. Being considered the background of biological evolution in nature, the theory of TCM is a macro summary of the micro material operation law of life for the ancient doctors. In essence, it is a revelation of the interaction law of "molecular society" between human body and nature, which often used to expressing the operation law of natural life science with the language of humanities and social sciences, with the characteristics of blending humanities and nature, and with the interdisciplinary. However, in order to solve the problem of modernization of TCM theory, it is necessary to find a discipline with the attribute of human, society and nature from modern natural science, and which can reflect the essential law of the evolution of life body, and that is biological supramolecular chemistry. Hence, our team started the exploratory research on the modern interpretation of TCM theoretical supramolecular chemistry, such as the basic theory of TCM, meridian, drug properties, pharmacology, variety attribution, processing, pharmaceutics and quality control, etc. in 2011, gradually expounded the solutions to three major scientific frontier problems and three major engineering and technical problems in the development of TCM, and finally had established a modern interpretation system of TCM supramolecular "Qi chromatography" theory. |
| Key words: traditional Chinese medicine basic theory of traditional Chinese medicine supramolecular chemistry Qi chromatography scientific frontier issues engineering and technical problems modernization of traditional Chinese medicine methodology |
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