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颜春薇,蒋鹏飞,彭俊,刘冬华,曾志成,彭清华.基于数据挖掘分析彭清华教授治疗青光眼的用药经验[J].湖南中医药大学学报,2022,42(3):425-429[点击复制] |
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| 基于数据挖掘分析彭清华教授治疗青光眼的用药经验 |
| 颜春薇,蒋鹏飞,彭俊,刘冬华,曾志成,彭清华 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学, 湖南 长沙 410208;湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心, 湖南 长沙 410208;湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 采用数据挖掘方法分析彭清华教授治疗青光眼的用药规律。方法 收集2013年9月至2021年6月于彭清华教授门诊就诊的青光眼患者病历，将患者症状、证候、用药录入Excel 2010，根据朱文锋教授提出的证素辨证理论对证素进行标准化处理，采用古今医案云平台（V2.3）进行复方中药的频次与关联规则分析。结果 共纳入符合标准的青光眼患者103例，包含103首处方，常用中药20味，主要有茯苓、赤芍、当归、柴胡、甘草等。所有药物中，寒性药物频次最多，为513次，温性药物为400次，平性药物为270次；甘味药物为719次，辛味药物为468次，苦味药物为433次；药物归经中，肝经药物频次最多，为680次，脾经药物500次，肺经药物477次；药物功效以活血化瘀和利水渗湿最多，分别为184次和164次。药物关联规则共获得16项药物组合，按置信度从大到小排列，最常用的药物组合分别为车前子-赤芍、泽泻-赤芍等。药物聚类分析共获得5个聚类方。结论 彭清华教授治疗青光眼常用药物为茯苓、赤芍、当归、柴胡、甘草、车前子、川芎、泽泻等，常用治法为活血利水法。 |
| 关键词: 青光眼 活血利水法 青光安颗粒剂 青光安Ⅱ号方 关联规则 |
| DOI：10.3969/j.issn.1674-070X.2022.03.014 |
| 投稿时间：2021-08-04 |
| 基金项目:国家自然科学基金面上项目（81874492）；中医药防治五官科疾病湖南省重点实验室建设项目（2017TP1018）；国家中医药管理局中医眼科学重点学科建设项目（ZK1801YK015）；湖南中医药大学中医学国内一流建设学科建设项目；中医药防治眼耳鼻咽喉疾病湖南省重点实验室；湖南省自然科学基金青年基金项目（2020JJ5436）；中医药防治眼耳鼻咽喉疾病湖南省重点实验室开放基金项目（2018YZD02）；湖南中医药大学中医学一流学科开放基金重点项目（2021ZYX13）；湖南中医药大学"一方"研究生创新项目（2021YF03）。 |
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| Analysis of professor Peng Qinghua's medication experience in the treatment of glaucoma based on data mining |
| YAN Chunwei,JIANG Pengfei,PENG Jun,LIU Donghua,ZENG Zhicheng,PENG Qinghua |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine, Changsha, Hunan 410208, China;Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To analyze professor Peng Qinghua's medication rule for treating glaucoma by used data mining method. Methods The medical records of glaucoma patients who attended professor Peng Qinghua’s outpatient clinic from September 2013 to June 2021 were collected, the patient’s symptoms, syndromes, and medications were entered into Excel 2010. According to the syndrome differentiation theory proposed by professor Zhu Wenfeng, the syndrome elements were standardized, and ancient and modern medical records cloud platform (V2.3) was used to analyze the frequency and association rules of compound Chinese medicines. Results A total of 103 eligible glaucoma patients were included, including 103 prescriptions, and 20 commonly used traditional Chinese medicines, there were mainly Fuling (Poria), Chishao (Paeoniae Radix Rubra), Danggui (Angelicae Sinensis Radix), Chaihu (Bupleuri Radix), Gancao (Glycyrrhizae Radix Et Rhizoma), etc. Among all drugs, cold drugs were the most frequently used, with 513 times, warm drugs were 400 times, and flat drugs were 270 times; sweet drugs were 719 times, pungent drugs were 468 times, and bitter drugs were 433 times; in the drug meridian, the liver meridian medicine was the most frequently used, with 680 times, the spleen meridian medicine was 500 times, and the lung meridian medicine was 477 times; the most effective drugs were activating blood circulation and removing blood stasis and diuresis and soaking dampness, with 184 times and 164 times respectively. A total of 16 drug combinations were obtained in the drug association rules, which were arranged in descending order of confidence, the most commonly used drug combinations were Cheqianzi (Plantaginis Semen)-Chishao (Paeoniae Radix Rubra), Zexie (Alismatis Rhizoma)-Chishao (Paeoniae Radix Rubra), etc. A total of 5 clustering prescriptions were obtained by drug cluster analysis. Conclusion Professor Peng Qinghua’s commonly used drugs for glaucoma treatment are Fuling (Poria), Chishao (Paeoniae Radix Rubra), Danggui (Angelicae Sinensis Radix), Chaihu (Bupleuri Radix), Gancao (Glycyrrhizae Radix Et Rhizoma), Cheqianzi (Plantaginis Semen), Chuanxiong (Chuanxiong Rhizoma), Zexie (Alismatis Rhizoma), etc. The commonly used treatment method is the method of activating blood and diuresis. |
| Key words: glaucoma activating blood and diuresis Qingguang’an Granule Qingguang’an Ⅱ prescription association rules |
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