| 引用本文: |
杨开锋,陈镇,成绍武,刘慧萍,李兰,周虹,邓桂明,肖小芹.化疗源性卵巢早衰的发生机制及中医药防治的研究进展[J].湖南中医药大学学报,2022,42(2):332-336[点击复制] |
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| 化疗源性卵巢早衰的发生机制及中医药防治的研究进展 |
| 杨开锋,陈镇,成绍武,刘慧萍,李兰,周虹,邓桂明,肖小芹 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410208;湖南中医药大学, 湖南 长沙 410208;湖南工商大学, 湖南 长沙 410208) |
| 摘要: |
| 随着化疗在癌症中的广泛应用，患者的生存率大大提高。然而，抗癌治疗往往也是导致卵巢早衰（premature ovarian failure，POF）的重要原因。目前认为，化疗药物可以通过诱导卵巢细胞凋亡、加速原始卵泡激活、增加卵巢微血管损伤而导致原始卵泡池（primordial follicles，PMFs）减小，进而引发POF和不孕。化疗源性POF西医病机复杂，但中医药亦可从“虚”和“瘀”论治。通过归纳整理化疗药物与卵巢损伤之间的联系，运用现代科学技术研发中医药，对于预防POF和保护女性生育能力至关重要。 |
| 关键词: 卵巢早衰 化疗 不孕 发生机制 中西医结合 |
| DOI：10.3969/j.issn.1674-070X.2022.02.028 |
| 投稿时间：2021-09-07 |
| 基金项目:湖南省自然科学基金面上项目（2020JJ4469）；湖南省中医药管理局科研计划项目重点项目（C2022008）；湖南省教育厅资助科研项目（21A0225）；湖南中医药大学中西医结合一流学科开放基金项目（2020ZXYJH58）。 |
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| Research progress on the mechanism of chemotherapy-induced premature ovarian failure and the prevention and treatment with traditional Chinese medicine |
| YANG Kaifeng,CHEN Zhen,CHENG Shaowu,LIU Huiping,LI Lan,ZHOU Hong,DENG Guiming,XIAO Xiaoqin |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan University of Technology and Business, Changsha, Hunan 410208, China) |
| Abstract: |
| With the widespread use of chemotherapy in cancer, the survival rate of patients has been greatly improved. However, anticancer therapy is often also an important cause of premature ovarian failure (POF). At present, it is believed that chemotherapeutic drugs can lead to the reduction of primordial follicles (PMFs) by inducing ovarian cell apoptosis, accelerating primordial follicle activation, and increasing ovarian microvascular injury, which in turn triggers POF and infertility. The western medicine pathogenesis of chemotherapy-induced POF is complex, but traditional Chinese medicine can also be treated from "deficiency" and "blood stasis". By summarizing and sorting out the relationship between chemotherapeutic drugs and ovarian injury, the use of modern science and technology to develop traditional Chinese medicine is essential for the prevention of POF and the protection of female fertility. |
| Key words: premature ovarian failure chemotherapy infertility mechanism integrated Chinese and western medicine |
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