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阎昱升,湛韬.六神胶囊联合磷酸奥司他韦胶囊治疗流行性感冒的临床研究[J].湖南中医药大学学报,2022,42(1):109-113[点击复制] |
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| 六神胶囊联合磷酸奥司他韦胶囊治疗流行性感冒的临床研究 |
| 阎昱升,湛韬 |
| (长沙市第一医院呼吸与危重症医学科, 湖南 长沙 410008;长沙市第一医院中西医结合科, 湖南 长沙 410008) |
| 摘要: |
| 目的 探讨六神胶囊联合磷酸奥司他韦胶囊治疗流行性感冒的临床疗效。方法 选取2018年9月至2019年12月长沙市第一医院收治的156例流行性感冒患者，完全随机分为观察组和对照组，每组78例。对照组口服磷酸奥司他韦胶囊（75 mg/次，2次/d），观察组在对照组的基础上给予六神胶囊（0.15 g/次，3次/d），两组均治疗5 d。患者体温>38.5℃时，可服用对乙酰氨基酚片，并记录服用量。比较两组患者治疗的有效率、对乙酰氨基酚使用情况、咽喉肿痛消退时间、咳嗽消退时间、流涕消退时间以及肌肉酸痛消退时间，检测治疗前及治疗5 d后的血清炎症因子CRP、TNF-α、IL-6水平，并观察两组患者不良反应的发生情况。结果 治疗后，观察组和对照组在治疗流感总有效率（P>0.05）方面无明显差异，但观察组痊愈率优于对照组（P<0.05）；治疗期间，观察组喉咙肿痛消退时间、流涕消退时间、肌肉酸痛消退时间均明显短于对照组（P<0.05），且六神胶囊联合磷酸奥司他韦胶囊可以明显减少对乙酰氨基酚使用量（P<0.05）；治疗前，两组患者血清炎症因子（CRP、TNF-α、IL-6）水平差异无统计学意义（P>0.05）；治疗5 d后，两组CRP、TNF-α、IL-6水平均显著降低，且观察组低于对照组，差异均有统计学意义（P<0.05）。治疗期间观察组和对照组不良反应发生率分别为7.69%和5.12%，差异无统计学意义（P>0.05）。结论 六神胶囊联合磷酸奥司他韦胶囊可有效缓解流行性感冒患者的临床症状、减轻炎症、加快病情好转、缩短流感患者病程，疗效优于磷酸奥司他韦胶囊单用。 |
| 关键词: 流行性感冒 六神胶囊 磷酸奥司他韦胶囊 热毒袭肺 炎症因子 |
| DOI：10.3969/j.issn.1674-070X.2022.01.022 |
| 投稿时间：2021-08-07 |
| 基金项目:湖南省自然科学基金项目（2018JJ6128）。 |
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| Clinical effect of Liushen Capsule combined with oseltamivir phosphate capsule in the treatment of patients with influenza |
| YAN Yusheng,ZHAN Tao |
| (Department of Respiratory and Critical Care Medicine, The First Hospital of Changsha, Changsha, Hunan 410008, China;Department of Integrated Traditional Chinese and Western Medicine, The First Hospital of Changsha, Changsha, Hunan 410008, China) |
| Abstract: |
| Objective To explore the clinical effect of Liushen Capsule combined with oseltamivir phosphate capsule in the treatment of patients with influenza. Methods A total of 156 patients with influenza admitted to The First Hospital of Changsha from September 2018 to December 2019 were selected and were randomly divided into observation group and control group, with 78 cases in each group. The control group took oseltamivir phosphate capsule (75 mg/time, twice a day). The observation group took Liushen Capsule (0.15 g/time, three times a day) on the basis of control group. Both groups were treated for 5 days. When the temperature was higher than 38.5℃, the patients could take acetyl aminophenol tablets and the dosage was recorded. The clinical efficacy and the use of acetaminophen were compared between the two groups of patients, and the throat swelling and pain, cough, sniffling and body ache disappearance time were recorded. Serum levels of inflammatory factors CRP, TNF-α and IL-6 were detected before and 5 days after treatment. Adverse drug reactions were observed in two groups. Results There was no significant difference between two groups in the effective rate of influenza treatment (P>0.05), but the cure rate of observation group was better than control group (P<0.05). During the treatment period, the disappearance time of throat swelling and pain, sniffling and body ache in observation group were shorter than those in control group (P<0.05). In addition, Liushen Capsule combined with oseltamivir phosphate capsule could also significantly reduce the use of acetyl aminophenol tablets in patients with influenza (P<0.05). Before treatment, there was no significant difference in the serum levels of CRP, TNF-α, IL-6 between the two groups (P>0.05); after 5 days of treatment, the serum levels of CRP, TNF-α, IL-6 in two groups were lowered, and the levels of these three inflammatory factors in observation group were lower than those in control group, the differences were statistically significant (P<0.05). The incidence of adverse drug reactions in the observation group and the control group were 7.69% and 5.12% respectively, and the difference was not statistically significant (P>0.05). Conclusion Liushen Capsule combined with oseltamivir phosphate capsule can effectively relieve the clinical symptoms of the patients with influenza, alleviate the inflammatory reactions, accelerate the recovery of the disease, shorten the duration of illness in influenza patients, and produce a better therapeutic effect than oseltamivir phosphate capsules alone. |
| Key words: influenza Liushen Capsule oseltamivir phosphate capsule hot poison attack the lungs inflammatory cytokines |
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