| 引用本文: |
陈定芳,吴月峰,桂卉,贺玉婷,李海英,肖美凤,周晋,周逸群,邓凯文,贺福元.水光谱组学研究现状及对中药归经理论的特殊影响[J].湖南中医药大学学报,2021,41(12):1986-1992[点击复制] |
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| 水光谱组学研究现状及对中药归经理论的特殊影响 |
| 陈定芳,吴月峰,桂卉,贺玉婷,李海英,肖美凤,周晋,周逸群,邓凯文,贺福元 |
| (湖南中医药大学药学院, 湖南 长沙 410208;中药药性与药效国家中医药管理局重点实验室, 湖南 长沙 410208;湖南中医药大学药学院, 湖南 长沙 410208;中药药性与药效国家中医药管理局重点实验室, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学药学院, 湖南 长沙 410208;中药药性与药效国家中医药管理局重点实验室, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学中医药超分子机理与数理特征化实验室, 湖南 长沙 410208) |
| 摘要: |
| 水光谱组学是一门研究水和水系统分子间氢键组成形态的新兴科学，它通过观察近红外光对水的作用所表征特征峰的变化来分析水系统中溶剂与溶质间的作用关系，且具有非侵入性、分析速度快和定性定量等特点，是研究中医经络及中药归经的有用工具。根据前期建立的中医药超分子“气析”理论，中药归经是中药成分客体与人体经络脏腑主体“印迹模板”自主选择性作用的结果，体现出以水为溶剂的体系的主体分子间非共价键作用特性，故水光谱组学可分析以水为溶剂系统人体的经络、腧穴、脏腑与中药分子的相互作用。本文先梳理水光谱组学的历史沿革、研究方法及其应用现状，再结合中药归经的超分子属性和亟待解决的主要问题，旨在阐明水光谱组学可用于测定人体经络脏腑的超分子结构特征，揭示具特殊基团“印迹模板”的中药归经微观物质基础。因此，水光谱组学将成为研究中药归经理论的有利工具，也是促进中医药现代化的有效方法。 |
| 关键词: 水光谱组学 近红外线 水 活性基团 中药归经理论 中医药现代化 |
| DOI：10.3969/j.issn.1674-070X.2021.12.030 |
| 投稿时间：2021-04-15 |
| 基金项目:国家自然科学基金项目（81703824，81803729，81903759，81874507）；湖南省科技厅重点实验室建设项目（2016TP1017）；湖南省自然科学基金项目（2019JJ50430）；湖南省教育厅创新平台开放基金项目（18K071）；湖南省“国内一流培育学科”药学2018年开放基金项目（2018YX06）；湖南中医药大学药学一流学科基金项目（2021YX15）。 |
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| Current Status of Hydrospectromics Research and Its Special Impact on Meridian Tropism Theory for the Chinese Materia Medica |
| CHEN Dingfang,WU Yuefeng,GUI Hui,HE Yuting,LI Haiying,XIAO Meifeng,ZHOU Jin,ZHOU Yiqun,DENG Kaiwen,HE Fuyuan |
| (College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Property and Pharmacodaynamic Key Laboratory of TCM, State Administration of Chinese Medicine, Changsha, Hunan 410208, China;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Property and Pharmacodaynamic Key Laboratory of TCM, State Administration of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Property and Pharmacodaynamic Key Laboratory of TCM, State Administration of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Aquaphotomics is an emerging science that studies the forming and its structure of hydrogen bonds among the pure water or water solvent systems. It analyzes the relationship between solvents and solutes in water systems by observing the changes in characteristic peaks interfered effectively by the near-infrared light, and has the characteristics of non-invasive, fast analysis and qualitative and quantitative analysis. It is a useful tool for studying the meridian for traditional Chinese medicine (TCM) and the meridian tropism for Chinese materia medica (CMM). According to the theory of supramolecular "Qi chromatography" of TCM established previously, the CMM meridian tropism theory is regarded the result of the autonomous and selective interaction between the guest molecule of CMM and the host molecule of meridians and viscera in humanbody with "imprinting templates", reflected the non-covalent bond characteristic interaction among the main molecules in water as solvent with solutes, so the aquaphotomics can monitor the process and results of molecular imprinting of meridians, acupoints, viscera by the CMM in the humanbody as water solvent system. This article has summarized the historical evolution of aquaphotomics, research methods and its application status, and thereby to combine the supramolecular properties and main problems in meridian tropism theory of the CMM that are urgently needed to clarify, and the illustration was given that the aquaphotomics can be used to determine the meridians and collaterals structure in the humanbody to reveal the characteristics of supramolecular structure with special "imprinting templates" groups as the microscopic material basis of TCM. Therefore, the aquaphotomics is a useful modern tool for studying the CMM meridian tropiam theory, as an effective method to promote the modernization of the TCM. |
| Key words: aquaphotomics near infrared water active group the Chinese materia media meridian tropism theory modernization of traditional Chinese medicine |
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