| 引用本文: |
李春蕊,胡素芹,许亚辉,刘殿龙,胡珂,崔力丹,郭健.通咽喷雾方对舌下神经损伤早期大鼠的吞咽功能及舌肌收缩张力的影响[J].湖南中医药大学学报,2021,41(12):1846-1850[点击复制] |
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| 通咽喷雾方对舌下神经损伤早期大鼠的吞咽功能及舌肌收缩张力的影响 |
| 李春蕊,胡素芹,许亚辉,刘殿龙,胡珂,崔力丹,郭健 |
| (北京中医药大学中医学院, 北京 102488) |
| 摘要: |
| 目的 探究通咽喷雾方对舌下神经损伤早期大鼠的吞咽功能及舌肌收缩张力的影响。方法 16只Wistar雄性大鼠，随机分为通咽喷雾方组和模型组，每组8只。两组大鼠均采用止血钳钳夹右侧舌下神经10 s进行造模。利用BL-420N生物信号采集器检测造模前、造模后以及滴舌给通咽喷雾方或蒸馏水10 min后大鼠的舌下神经放电积分面积、舌肌阈强度、舌肌单收缩幅度以及吞咽潜伏期及吞咽次数。结果 与造模前相比，造模后通咽喷雾方组和模型组大鼠舌下神经放电积分面积和舌肌单收缩幅度均减小（P<0.05），舌肌阈强度均增大（P<0.05）；给药后10 min，与造模后相比，通咽喷雾方组舌下神经放电积分面积和舌肌单收缩幅度均增大（P<0.05），舌肌阈强度减小（P<0.05），模型组的舌下神经放电积分面积、舌肌单收缩幅度与舌肌阈强度均无明显变化（P>0.05）。与造模前相比，造模后通咽喷雾方组与模型组的吞咽潜伏期和吞咽次数差异无统计学意义（P>0.05），给药后10 min通咽喷雾方组与模型组的吞咽潜伏期均无明显变化（P>0.05），但通咽喷雾方组的吞咽次数增多（P<0.05）。与模型组相比，给药后10 min大鼠舌下神经放电积分面积增加（P<0.05），舌肌单收缩幅度增加（P<0.05），吞咽次数增加（P<0.05）。结论 在舌下神经损伤早期，通咽喷雾方可通过提高舌下神经的兴奋性和舌肌的收缩张力，增加吞咽次数。 |
| 关键词: 通咽喷雾方 舌下神经损伤 吞咽功能 舌肌收缩张力 阈强度 单收缩幅度 舌下神经放电 |
| DOI：10.3969/j.issn.1674-070X.2021.12.006 |
| 投稿时间：2021-02-11 |
| 基金项目:国家自然科学基金项目（81473623）；北京中医药大学科研纵向发展基金项目（2019ZXFZJJ021）。 |
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| The Effect of Tongyan Spray on Swallowing Function and Tongue Muscle Contraction Tension in Rats with Early Hypoglossal Nerve Injury |
| LI Chunrui,HU Suqin,XU Yahui,LIU Dianlong,HU Ke,CUI Lidan,GUO Jian |
| (School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China) |
| Abstract: |
| Objective To explore the effect of Tongyan Spray on swallowing function and tongue muscle contraction tension in rats with early hypoglossal nerve injury. Methods 16 Wistar male rats were randomly divided into Tongyan Spray group and model group, with 8 rats in each group. Both groups of rats were modeled by clamping the right hypoglossal nerve with hemostatic forceps for 10 s. The BL-420N biosignal collector was used to detect the integral area of hypoglossal nerve discharge, the threshold intensity of the tongue muscle, the amplitude of single contraction of the tongue muscle, swallowing latency and swallowing times before and after the modeling and 10 min after the tongue was sprayed with Tongyan Spray or distilled water. Results Compared with before modeling, the integral area of hypoglossal nerve discharge and the amplitude of single contraction of the tongue muscle in the Tongyan Spray group and the model group were reduced after modeling (P<0.05), and the threshold intensity of the tongue muscle was increased(P<0.05); after administration for 10 min, compared with after modeling, the integral area of hypoglossal nerve discharge and the amplitude of single contraction of tongue muscle in Tongyan Spray group increased (P<0.05), and the threshold intensity of tongue muscle decreased (P<0.05), there were no significant changes in the integral area of hypoglossal nerve discharge, the amplitude of single contraction of the tongue muscle and the threshold intensity of the tongue muscle in the model group (P>0.05). Compared with before modeling, there was no significant difference in swallowing latency and swallowing times between Tongyan Spray group and model group after modeling (P>0.05). After administration for 10 min, the swallowing latency of Tongyan Spray group and model group were both no significant change (P>0.05), but the swallowing times in the Tongyan Spray group increased (P<0.05). Compared with the model group, the integral area of hypoglossal nerve discharge increased (P<0.05), the amplitude of single contraction of the tongue muscle increased (P<0.05), and the swallowing times increased (P<0.05) after 10 min of administration. Conclusion In the early stage of hypoglossal nerve injury, Tongyan Spray can increase the frequency of swallowing by increasing the excitability of the hypoglossal nerve and the contraction tension of the tongue muscle. |
| Key words: Tongyan Spray hypoglossal nerve injury swallowing function contraction tension of the tongue muscle threshold intensity single contraction amplitude hypoglossal nerve discharge |
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