| 引用本文: |
袁汉文,李琳,吕梦颖,罗江溢,刘杨,彭彩云,王炜.基于薄层色谱的枳实与其混伪品鉴别研究[J].湖南中医药大学学报,2021,41(10):1534-1539[点击复制] |
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| 基于薄层色谱的枳实与其混伪品鉴别研究 |
| 袁汉文,李琳,吕梦颖,罗江溢,刘杨,彭彩云,王炜 |
| (湖南中医药大学中医药民族医药国际联合实验室, 湖南 长沙 410208;湖南中医药大学中医药民族医药国际联合实验室, 湖南 长沙 410208;湖南省食品药品检验研究院, 湖南 长沙 410001) |
| 摘要: |
| 目的 对比枳实与其易混淆品枳壳、青皮、陈皮的薄层色谱鉴别方法，以期筛选更科学合理的鉴别方法，将其纳入《美国药典》和《欧洲药典》标准。方法 采用《中华人民共和国药典》《台湾中药典》《香港中药材标准》以及《中药色谱指纹图谱精细分析图集》所记载的枳实、枳壳、陈皮、青皮4味中药材的薄层色谱鉴别方法，对4味药材化学成分差异性进行系统分析研究。结果 对通过13种薄层色谱方法得到的色谱图进行对比分析，发现2020版《中华人民共和国药典》中枳壳的方法对枳实和其易混淆品种青皮和陈皮的鉴别效果较好。结论 4味药材化学成分具有较高的相似性，各版本药典中4味药材的薄层色谱鉴别方法均能对四者化学成分进行分析，但绝大部分方法没有特异性，无法区分四者。 |
| 关键词: 枳实 枳壳 青皮 陈皮 薄层色谱 鉴别 |
| DOI：10.3969/j.issn.1674-070X.2021.10.011 |
| 投稿时间：2021-05-26 |
| 基金项目:国家重点研发计划“中医药现代化研究”专项“中药国际标准示范研究”（2018YFC1707903）；长沙市自然科学基金资助项目（kq2014086）；湖南省教育厅科研项目（20K095）。 |
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| Research on Discrimination of Zhishi (Aurantii Fructus Immaturus) From Its Commonly Known Adulterants Based on Thin Layer Chromatography |
| YUAN Hanwen,LI Lin,LV Mengying,LUO Jiangyi,LIU Yang,PENG Caiyun,WANG Wei |
| (TCM and Ethnomedicine Innovation & Development International Laboratory, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;TCM and Ethnomedicine Innovation & Development International Laboratory, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Institute for Food and Drug Control, Changsha, Hunan 410001, China) |
| Abstract: |
| Objective To compare the thin layer chromatography method for the identification of Zhiqiao (Aurantii Fructus), Qingpi (Citri Reticulatae Pericarpium Viride) and Chenpi (Citri Reticulatae Pericarpium), screen out the best one, and help to develop reasonable and scientific standards of American Pharmacopoeia and European Pharmacopoeia. Methods The differences of chemical components of four kinds of Chinese herbal medicines, namely, Zhishi (Aurantii Fructus Immaturus), Zhiqiao (Aurantii Fructus), Qingpi (Citri Reticulatae Pericarpium Viride) and Chenpi (Citri Reticulatae Pericarpium), were systematically analyzed and studied by thin layer chromatography method recorded in Chinese Pharmacopoeia, Taiwan Traditional Chinese Medicine Dictionary, Hong Kong Standard of Chinese Herbal Medicines and Atlas of Fine Analysis of Chromatographic Fingerprint of Chinese Herbal Medicines. Results The results found the method in Chinese Pharmacopoeia (2020 edition) showed the method of Zhiqiao (Aurantii Fructus) had better discrimination effect on Zhishi (Aurantii Fructus Immaturus) and its commonly known adulterants, after comparison of 13 methods in the pharmacopeia. Conclusion The four herbal medicines showed high similarity in chemical constituents. All the methods can be used for the analysis of the herbs, but most of them have the shortcomings of poor specificity and can not be used to distinguish the four herbs. |
| Key words: Zhishi (Aurantii Fructus Immaturus) Zhiqiao (Aurantii Fructus) Qingpi (Citri Reticulatae Pericarpium Viride) Chenpi (Citri Reticulatae Pericarpium) thin layer chromatography discrimination |
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