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李英,屈金艳,王孟清,高尚,罗银河,丁伊,舒文豪,江志豪.银黄清肺胶囊治疗小儿病毒性肺炎痰热闭肺证的临床观察[J].湖南中医药大学学报,2021,41(9):1447-1451[点击复制] |
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| 银黄清肺胶囊治疗小儿病毒性肺炎痰热闭肺证的临床观察 |
| 李英,屈金艳,王孟清,高尚,罗银河,丁伊,舒文豪,江志豪 |
| (湖南中医药大学第一附属医院, 湖南 长沙, 410007;湖南安邦制药股份有限公司, 湖南 长沙 410008;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察银黄清肺胶囊治疗小儿病毒性肺炎痰热闭肺证的疗效及安全性。方法 选取2019年2月至2019年12月在湖南中医药大学第一附属医院儿科住院的85例病毒性肺炎痰热闭肺证患儿，将其随机分为观察组（45例）和对照组（40例）。对照组采用利巴韦林治疗，观察组采用银黄清肺胶囊治疗，两组均治疗10 d。治疗前后记录两组症状体征消失时间、炎性因子（TNF-α、IL-6、IL-8、IL-10、IL-17、TGF-β1）水平、免疫球蛋白（IgG、IgA、IgM）水平、T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）水平，比较两组临床疗效，并记录不良事件。结果 治疗后，观察组临床疗效优于对照组（P<0.05），且观察组退热时间、咳嗽及喘息消失时间较对照组短（P<0.05）；治疗后，两组TNF-α、IL-6、IL-8、IL-10、IL-17、TGF-β1水平较治疗前降低（P<0.05），且观察组低于对照组（P<0.05）；两组治疗后CD4+、CD4+/CD8+水平较治疗前均降低（P<0.05），两组治疗后CD8+水平较治疗前均升高（P<0.05），观察组治疗后CD3+水平较治疗前升高（P<0.05）；治疗后，观察组CD3+、CD8+水平较对照组均升高（P<0.05），观察组CD4+、CD4+/CD8+水平较对照组均降低（P<0.05）；两组治疗后IgG、IgM水平较治疗前升高（P<0.05）；治疗后，观察组IgG、IgM水平较对照组升高（P<0.05）；两组在治疗期间未发现不良反应。结论 银黄清肺胶囊治疗小儿病毒性肺炎有很好的临床疗效，可缩短肺炎症状体征消失的时间，使患儿各项炎症指标恢复正常，并且促进免疫球蛋白上升，提高免疫力。 |
| 关键词: 病毒性肺炎 银黄清肺胶囊 小儿 痰热闭肺证 临床观察 |
| DOI：10.3969/j.issn.1674-070X.2021.09.024 |
| 投稿时间：2021-06-25 |
| 基金项目:湖南省科技创新计划项目（2018TP2034）；湖南中医药大学中医学国内一流学科建设学科项目（4901-020002002）。 |
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| Clinical Observation on Yinhuang Qingfei Capsule in Treating Viral Pneumonia with Accumulation of Phlegm-heat Syndrome in Children |
| LI Ying,QU Jinyan,WANG Mengqing,GAO Shang,LUO Yinhe,DING Yi,SHU Wenhao,JIANG Zhihao |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan Anbang Pharmaceutical Co., Ltd., Changsha, Hunan 410008, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the efficacy and safety of Yinhuang Qingfei Capsule in the treatment of viral pneumonia with accumulation of phlegm-heat syndrome in children. Methods A total of 85 children with viral pneumonia with accumulation of phlegm-heat syndrome who were hospitalized in the Department of Pediatrics of The First Affiliated Hospital of Hunan University of Chinese Medicine from February 2019 to December 2019 were selected. They were randomly divided into observation group (45 cases) and control group (40 cases). The control group was treated with ribavirin, the observation group was treated with Yinhuang Qingfei Capsule, both groups were treated for 10 days. The disappearance time of symptoms and signs, inflammatory factors (TNF-α、IL-6、IL-8、IL-10、IL-17、TGF-β1) and immunoglobulin (IgG、IgA、IgM), T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) content in the two groups were recorded before and after treatment. The clinical efficacy of the two groups were compared and adverse events were recorded. Results After treatment, the total effective rate of observation group was better than control group (P<0.05), and the fever relieving time, cough and wheezing disappearance time in the observation group were shorter than those in the control group (P<0.05). After treatment, the levels of TNF-α, IL-6, IL-8, IL-10, IL-17 and TGF-β1 in the two groups were significantly decreased compared with those before treatment (P<0.05), and the observation group were lower than those in the control group (P<0.05). The levels of CD4+ and CD4+/CD8+ in both groups decreased after treatment compared with before treatment (P<0.05), the level of CD8+ in both groups increased after treatment compared with before treatment (P<0.05), the level of CD3+ in observation group increased after treatment compared with before treatment (P<0.05). After treatment, the levels of CD3+ and CD8+ were increased in the observation group compared with the control group (P<0.05), and the levels of CD4+ and CD4+/CD8+ were decreased in the observation group compared with the control group (P<0.05). After treatment, the levels of IgG and IgM in both groups were higher than those before treatment (P<0.05). After treatment, IgG and IgM levels in observation group were higher than those in control group (P<0.05). No adverse reactions were found in the two groups during treatment. Conclusion Yinhuang Qingfei Capsule is safe and effective in the treatment of children with viral pneumonia with accumulation of phlegm-heat syndrome, which can shorten the time of the symptoms and signs of pneumonia disappear, normalize the inflammatory indicators of children, promote the rise of immunoglobulin, and improve immunity. |
| Key words: viral pneumonia Yinhuang Qingfei Capsules children accumulation of phlegm-heat syndrome clinical observation |
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