Analysis on Characteristics of Traditional Chinese Patent Compound for Hyperthyroidism
YE Zhenghua,JIA Mian,YE Hui,GAO Mingsong
(Wuhan No.1 Hospital, Wuhan, Hubei 430022, China;Traditional Knowledge Protecting Center, World Federation of Chinese Medicine Societies, Beijing 100101, China;Peking University First Hospital, Beijing 100034, China)
Abstract:
Objective To analyze the characteristics of traditional Chinese patent compounds for hyperthyroidism base on the China Knowledge Network Infrastructure (CNKI) database and the SooPAT database. Methods Data of traditional Chinese medicine (TCM) patent compounds for hyperthyroidism were searched and screened in CNKI database and the SooPAT database. Frequency counting, cluster analysis and association analysis of TCM were performed using Ancient and Modern Medical Case Cloud Platform (V2.2.3) to mine and reveal the consisting rules and characteristics of these patent compounds. Results 110 TCM patent compounds for hyperthyroidism were enrolled. Drug attribute frequency analysis showed the herbs were predominantly bitter, cold, and sweet in properties, and mainly passed through liver and lung meridian. The top 10 frequent herbs were Xiakucao (Prunellae Spica), Muli (Ostreae Concha), Baishao (Paeoniae Radix Alba), Huangqi (Astragali Radix), Shengdihuang (Rehmanniae Radix), Haizao (Sargassum), Danggui (Angelicae Sinensis Radix), Maidong (Ophiopogonis Radix), Xuanshen (Scrophulariae Radix), Chaihu (Bupleuri Radix). Association analysis revealed 11 pairs of herbs, the combinations of Haizao (Sargassum)-Kunbu (Laminariae Thallus Eckloniae Thallus), Haizao (Sargassum)-Kunbu (Laminariae Thallus Eckloniae Thallus)-Xiakucao (Prunellae Spica) had over 15% support rating. Cluster analysis based on top 30 herbs concluded 6 kinds of formulations. Network analysis generated a core network with 26 herbs, in which Xiakucao (Prunellae Spica)-Muli (Ostreae Concha) has the strongest connection, followed by Xiakucao (Prunellae Spica)-Haizao (Sargassum). Conclusion The main effect of traditional Chinese patent compounds for hyperthyroidism was dispersing goiter and dissipating binds, accompanied with clearing heat, softening hard and resolving phlegm. The primary herb were Xiakucao (Prunellae Spica), Haizao (Sargassum), Kunbu (Laminariae Thallus Eckloniae Thallus), Muli (Ostreae Concha).