| 引用本文: |
朱志飞,刘有志,吴月峰,陈定芳,唐总德,周琦人,李冰杰,刘健康,周晋,贺福元.经典名方身痛逐瘀汤药材精准炮制方法的研究[J].湖南中医药大学学报,2021,41(8):1204-1210[点击复制] |
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| 经典名方身痛逐瘀汤药材精准炮制方法的研究 |
| 朱志飞,刘有志,吴月峰,陈定芳,唐总德,周琦人,李冰杰,刘健康,周晋,贺福元 |
| (湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学中医药超分子机理与数理特征化实验室, 湖南 长沙 410208) |
| 摘要: |
| 目的 对身痛逐瘀汤中各药材进行最佳炮制工艺研究，为身痛逐瘀汤"物质基准"的制备工艺研究提供实验基础。方法 以道地药材为原料，测定各药材2020版《中华人民共和国药典》中指标成分以及浸出物的含量，并以此为单因素考察指标，从喷水量、喷淋次数、闷润时间、切制规格、干燥温度和炒制时间、炒制温度等多方面进行考察，取最相关因素进行方差分析，以及建立单成分炮制火候模型，最终确定最佳炮制工艺。结果 经过单因素和正交实验综合得，当归药材的最佳炮制工艺为初步净制后，闷润时间2 h，切制1~2 mm，60℃干燥；甘草药材的最佳炮制工艺为初步净制后，蒸制时间30 min，切制1~2 mm，80℃干燥；牛膝药材的最佳炮制工艺为初步净制，闷润时间1.0 h，切制7~8 mm，70℃干燥；秦艽药材的最佳炮制工艺为初步净制后喷秦艽重量0.5倍的水3次，闷润0.5 h，切制9~10 mm，70℃干燥；羌活药材的最佳炮制工艺为初步净制，喷羌活重量0.8倍的水3次，闷润2.5 h，切制7~8 mm，50℃干燥；川芎药材的最佳炮制工艺为初步净制，浸泡时间2 h，润软12 h后，切制9~10 mm，50℃干燥；地龙的最佳炮制工艺，即加地龙重量2倍水，淘洗时间2 min，切制3~4 mm，80℃干燥；桃仁的最佳炮制工艺即沸水烫时间5 min，冷水浸泡冷却1 min，80℃干燥；红花药材的炮制为取红花原药材，除去杂质、花萼及花柄，筛去灰屑，制得红花炮制品；香附药材的炮制为除去毛须及杂质，碾碎，得香附炮制品；没药药材的炮制为拣净杂质，大颗粒的没药碾碎为小颗粒，即得没药的炮制品；五灵脂药材为清炒，具体炮制火候模型为H原儿茶酸=15.68 0.139 8/T2e686.37/T。对最佳炮制工艺下炮制的炮制品进行性状、水分及指标成分含量鉴定，12味饮片含量及性状鉴定均符合2020版《中华人民共和国药典》中水分含量的标准，15批饮片质量初步符合标准。结论 本实验确定的身痛逐瘀汤中12味药材的炮制工艺可行，可为身痛逐瘀汤物质基础的制备工艺提供依据。 |
| 关键词: 身痛逐瘀汤 经典名方 炮制 工艺研究 单因素 正交设计 炮制火候模型 |
| DOI：10.3969/j.issn.1674-070X.2021.08.011 |
| 投稿时间：2021-04-09 |
| 基金项目:国家自然科学基金项目（81903759，81874507）；湖南省教育厅项目（18K071）；湖南"国内一流培育学科"药学开放基金项目（2018XY09）；国家留学基金资助项目（201708430243）；长沙市科学技术局项目（kq2004059）；省级大学生创新训练计划项目（S202110541070）；湖南中医药大学2020年度大学生创新创业训练计划项目（114）。 |
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| A Study on the Precise Processing Method of the Classical Prescription Shentong Zhuyu Decoction |
| ZHU Zhifei,LIU Youzhi,WU Yuefeng,CHEN Dingfang,TANG Zongde,ZHOU Qiren,LI Bingjie,LIU Jiankang,ZHOU Jin,HE Fuyuan |
| (College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Key Laboratory of Druggability and Preparation Modification of TCM, Changsha, Hunan 410208, China;Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To study the best processing technology of Shentong Zhuyu Decoction, and to provide experimental basis for the preparation technology of Shentong Zhuyu Decoction. Methods Genuine medicinal materials was used as raw materials, the determination of the content of index components and extracts in Chinese Pharmacopoeia 2020 edition of medicinal materials was taken as the single factor index, and the water spraying amount, spraying times, moistening time, cutting specifications, drying temperature and frying time, frying temperature and other aspects were investigated. The most relevant factors were selected for variance analysis, and the single component processing fire model was established. Finally, the best processing technology was determined. Results Through single factor and orthogonal experiments, the best processing technology of Danggui (Angelicae Sinensis Radix) was as follows:after preliminary purification, moistening time was 2 hours, cutting 1~2 mm, drying at 60℃; the best processing technology of Gancao (Glycyrrhizae Radix Et Rhizoma) was as follows:after preliminary purification, steaming time was 30 minutes, cutting 1~2 mm, drying at 80℃; the best processing technology of Niuxi (Achyranthis Bidentatae Radix) was as follows:preliminary purification, moistening time was 1 hour, cutting 7~8 mm, drying at 70℃; the best processing technology of Qinjiao (Gentianae Macrophyllae Radix) was as follows:spray water 0.5 times the weight of Qinjiao (Gentianae Macrophyllae Radix) three times, moistening 0.5 hours, cutting 9~10 mm, drying at 70℃; the best processing technology of Qianghuo (Notopterygii Rhizoma Et Radix) was as follows:spray water 0.8 times the weight of Qianghuo (Notopterygii Rhizoma Et Radix) three times, moistening 2.5 hours, cutting 7~8 mm, drying at 50℃; the best processing technology of Chuanxiong (Chuanxiong Rhizoma) was as follows:initial purification, soaking for 2 hours, moistening for 12 hours, cutting 9~10 mm, drying at 50℃; the best processing technology of Dilong (Pheretima) was adding 2 times of Dilong (Pheretima) weight water, washing time was 2 minutes, cutting 3~4 mm, drying at 80℃; the best processing technology of Taoren (Persicae Semen) was boiling water for 5 minutes, soaking in cold water for 1 minute, drying at 80℃; the processing technology of Honghua (Carthami Flos) medicinal material was taking safflower raw material, removing impurities, calyx and flower stalk, screening ash to get Honghua (Carthami Flos) processed products; the processing technology of Xiangfu (Cyperi Rhizoma) medicinal material was picking up the impurities and grinding them to obtain Xiangfu (Cyperi Rhizoma) processed products; the processing of Moyao (Myrrha) medicinal material was sorting out impurities, and grinding the large particles of Moyao (Myrrha) into small particles to obtain Moyao (Myrrha) processed products; Wulingzhi (Faeces Trogopterori) medicinal materials were stir-fried, and the specific processing model was H原儿茶酸=15.68 0.139 8/T2e686.37/T. The properties, moisture content and index component content of processed products processed under the best processing technology were identified. The results showed that the content and properties of 12 decoction pieces were in accordance with the standard of water content in Chinese Pharmacopoeia 2020 edition, and the quality of 15 batches of decoction pieces was in line with the standard. Conclusion The processing technology of 12 herbs in Shentong Zhuyu Decoction is feasible, which can provide the basis for the preparation of material basis of Shentong Zhuyu Decoction. |
| Key words: Shentong Zhuyu Decoction classic famous prescription processing process research single factor orthogonal design processing fire syndrome model |
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