| 引用本文: |
省格丽,刘晶晶,于泽丛,周雪忠,杨颐.基于复杂网络的国医大师沈宝藩治疗冠心病用药规律分析[J].湖南中医药大学学报,2021,41(7):986-991[点击复制] |
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| 基于复杂网络的国医大师沈宝藩治疗冠心病用药规律分析 |
| 省格丽,刘晶晶,于泽丛,周雪忠,杨颐 |
| (新疆医科大学附属中医医院, 新疆 乌鲁木齐 830000;北京交通大学计算机与信息技术学院, 北京 100044) |
| 摘要: |
| 目的 以国医大师沈宝藩临床处方数据为出发点，基于复杂网络的中药网络和处方网络相结合，探索沈教授治疗冠心病的常用核心处方、核心药物应用规律。方法 收集沈宝藩教授2018年10月1日至2020年12月31日治疗冠心病的门诊处方，将全部处方录入结构化的临床诊疗信息采集系统，转化为可分析数据，再利用复杂网络分析算法与复杂网络分析系统分析沈宝藩教授治疗冠心病的处方用药规律。结果 共纳入沈宝藩教授治疗冠心病处方1 976首，共涉及中药197味，使用频次较高的前5位药物依次为川芎、丹参、陈皮、当归、红花。药性以温性、平性、寒性为主。药味以甘味、苦味、辛味为主。常用活血、安神、理气、化痰之法。高频药物关联规则显示，支持度最高的前3位药对为川芎-丹参、川芎-红花、丹参-当归。基于复杂网络分析，得到核心处方药物：当归、丹参、川芎、红花、葛根、郁金、首乌藤、生地黄、太子参、炒酸枣仁、陈皮、炙甘草。结论 沈宝藩教授治疗冠心病常用活血、安神、理气、化痰之法，以痰瘀为病机核心，痰瘀同治。 |
| 关键词: 冠心病 痰瘀同治 数据挖掘 复杂网络分析 川芎 丹参 陈皮 沈宝藩 |
| DOI：10.3969/j.issn.1674-070X.2021.07.003 |
| 投稿时间：2021-02-24 |
| 基金项目:国家中医药管理局“国医大师沈宝藩传承工作室”建设项目；国医大师沈宝藩工作室建设项目（新中民医药办科函[2018]4号）；新疆医科大学附属中医医院院级课题（ZYY2019MY05）。 |
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| Analysis of the Rule of Chinese Medicine Master Shen Baofan in the Treatment of Coronary Heart Disease Based on Complex Network |
| XIN Geli,LIU Jingjing,YU Zecong,ZHOU Xuezhong,YANG Yi |
| (Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China;School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China) |
| Abstract: |
| Objective To explore the commonly used core prescriptions and core drug application rules for the treatment of coronary heart disease by professor Shen Baofan, a master of traditional Chinese medicine (TCM), through taking the clinical prescription data of Shen as the starting point, combined with the complex network-based TCM network and prescription network. Methods Professor Shen Baofan's outpatient treatments for coronary heart disease from October 1, 2018 to December 31, 2020 were collected, all prescriptions were entered into a structured clinical diagnosis and treatment information collection system, and converted into analyzable data, and then complex network analysis algorithms and complexity network analysis system were used to analyze professor Shen Baofan's prescription medication rules for coronary heart disease. Results A total of 1 976 prescriptions for the treatment of coronary heart disease by professor Shen Baofan were included, involving a total of 197 Chinese medicines. The top 5 medicines with a higher frequency of use were Chuanxiong (Chuanxiong Rhizoma), Danshen (Salviae Miltiorrhizae Radix Et Rhizoma), Chenpi (Citri Reticulatae Pericarpium), Danggui (Angelicae Sinensis Radix), and Honghua (Carthami Flos). The medicinal properties were mainly warm, flat and cold. The medicinal taste was mainly sweet, bitter and pungent. Commonly used methods were promoting blood circulation, calming the mind, regulating Qi, and eliminating phlegm. The high-frequency drug association rules showed that the top 3 drug pairs with the highest support were Chuanxiong (Chuanxiong Rhizoma)-Danshen (Salviae Miltiorrhizae Radix Et Rhizoma), Chuanxiong (Chuanxiong Rhizoma)-Honghua (Carthami Flos), and Danshen (Salviae Miltiorrhizae Radix Et Rhizoma)-Danggui (Angelicae Sinensis Radix). Based on complex network analysis, core prescription drugs were obtained:Danggui (Angelicae Sinensis Radix), Danshen (Salviae Miltiorrhizae Radix Et Rhizoma), Chuanxiong (Chuanxiong Rhizoma), Honghua (Carthami Flos), Gegen (Puerariae Lobatae Radix), Yujin (Curcumae Radix), Shouwuteng (Polygoni Multiflori Caulis), Shengdihuang (Rehmanniae Radix), Taizishen (Pseudostellariae Radix), Chaosuanzaoren (Ziziphi Spinosae Semen), Chenpi (Citri Reticulatae Pericarpium), Zhigancao (Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle). Conclusion Professor Shen Baofan usually uses the methods of promoting blood circulation, calming mind, regulating Qi, and resolving phlegm in the treatment of coronary heart disease. Phlegm and blood stasis are the core of the pathogenesis, and phlegm and blood stasis are treated at the same time. |
| Key words: coronary heart disease simultaneous treatment of phlegm and blood stasis data mining complex network analysis Chuanxiong (Chuanxiong Rhizoma) Danshen (Salviae Miltiorrhizae Radix Et Rhizoma) Chenpi (Citri Reticulatae Pericarpium) Shen Baofan |
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