| 引用本文: |
李跃兵,贺子毅,刘奕君,李姝悦,彭艳.电针足三里对功能性消化不良大鼠胃肠动力调节机制研究[J].湖南中医药大学学报,2021,41(6):928-933[点击复制] |
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| 电针足三里对功能性消化不良大鼠胃肠动力调节机制研究 |
| 李跃兵,贺子毅,刘奕君,李姝悦,彭艳 |
| (湖南中医药大学针灸推拿学院, 湖南 长沙 410208) |
| 摘要: |
| 目的 探讨电针干预功能性消化不良的可能作用机制。方法 将25只SD大鼠随机分为空白组、模型组、电针组、电针非穴位组、多潘立酮组，每组5只。除空白组外，其余各组采用多因素干预法制造功能性消化不良大鼠模型。造模成功后，模型组不采用干预措施，电针组采用电针足三里穴，电针非穴位组采用电针足三里外2 mm处非穴位点，多潘立酮组采用多潘立酮灌胃，均干预14 d。干预结束后，观察各组大鼠行为学、食量与体质量增长情况、肠道敏感性、胃排空率、小肠推进率、胃动素、胃泌素、血管活性肽的变化。结果 与空白组比较，模型组大鼠体质量与食量降低，活动度减少，肠道敏感性、胃内残留率增加，小肠推进率、胃动素、胃泌素降低，血管活性肽升高（P<0.05）；与模型组相比，电针组、多潘立酮组、电针非穴位组大鼠体质量与食量升高，活动度增加，肠道敏感性、胃内残留率降低，小肠推进率增加，胃动素、胃泌素升高，血管活性肽降低（P<0.05）；与电针非穴位组比较，电针组、多潘立酮组大鼠体质量与食量升高，活动度增加，肠道敏感性、胃内残留率降低，小肠推进率增加，胃动素、胃泌素升高，血管活性肽降低（P<0.05）；与多潘立酮组比较，电针组大鼠体质量与食量升高，活动度增加，肠道敏感性、胃内残留率降低，小肠推进率增加，胃动素、胃泌素升高，血管活性肽降低（P<0.05）。结论 电针能改善功能性消化不良大鼠食欲和运动行为、增加体质量与食量、降低肠道敏感性，促进胃的排空和小肠的推进功能，电针上述作用可能是通过升高血清中胃动素及胃泌素的含量、降低血管活性肽的含量来实现的。 |
| 关键词: 电针 足三里 功能性消化不良 胃肠动力 胃动素 胃泌素 |
| DOI：10.3969/j.issn.1674-070X.2021.06.021 |
| 投稿时间：2021-01-10 |
| 基金项目:国家自然科学基金项目（81774431）；湖南省国内一流培育学科中西医结合开放基金项目（2020ZXYJH16）；湖南中医药大学校级科研基金项目（2018XJJJ25）；湖南中医药大学优秀教师培养计划（青苗计划）。 |
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| Regulation Mechanism of Electroacupuncture at Zusanli (ST36) on Gastrointestinal Motility in Rats with Functional Dyspepsia |
| LI Yuebing,HE Ziyi,LIU Yijun,LI Shuyue,PENG Yan |
| (College of Acupuncture and Massage, Hunan University of Chinese medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To explore the possible mechanism of electroacupuncture (EA) intervention on functional dyspepsia. Methods 25 SD rats were randomly divided into blank group, model group, EA group, EA non acupoint group and domperidone group, with 5 rats in each group. In addition to the blank group, the other groups were made functional dyspepsia rat model by multi factor intervention. After successful modeling, the model group was not intervened, the EA group was treated with EA at Zusanli (ST36), the EA non acupoint group was treated with EA at non acupoint 2 mm outside Zusanli (ST36), and the domperidone group was treated with domperidone by gavage for 14 days. After the intervention, the changes of behavior, food intake and body weight growth, intestinal sensitivity, gastric emptying rate, intestinal propulsion rate, motilin, gastrin and vasoactive peptide were observed. Results Compared with the blank group, the weight and food intake of rats in the model group decreased, the activity decreased, the intestinal sensitivity and the gastric residual rate increased, the intestinal propulsion rate, the motilin and gastrin decreased, and the vasoactive peptide increased (P<0.05); compared with the model group, the body weight and food intake of rats in EA group, domperidone group and EA non acupoint group increased, the activity increased, the intestinal sensitivity and the gastric residual rate decreased, the intestinal propulsion rate increased, the motilin and gastrin increased, and the vasoactive peptide decreased (P<0.05); compared with the EA non acupoint group, the body weight and food intake of rats in the EA group and domperidone group increased, the activity increased, the intestinal sensitivity and the gastric residual rate decreased, the intestinal propulsion rate increased, the motilin and gastrin increased, and the vasoactive peptide decreased (P<0.05); compared with the domperidone group, the body weight and food intake of the EA group increased, the activity increased, the intestinal sensitivity and the gastric residual rate decreased, the intestinal propulsion rate increased, the motilin and gastrin increased, and the vasoactive peptide decreased (P<0.05). Conclusion EA can improve appetite and exercise behavior, increase body weight and food intake, reduce intestinal sensitivity, promote gastric emptying and intestinal propulsion in rats with functional dyspepsia. The above effects of EA may be achieved by increasing the contents of motilin and gastrin in serum and reducing the contents of vasoactive peptide. |
| Key words: electroacupuncture Zusanli (ST36) functional dyspepsia gastrointestinal motility motilin gastrin |
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