| 引用本文: |
杨娅婕,赵宁,曹玉婷,王桂喜.重复经颅磁刺激干预中枢神经系统疾病的生物标志物研究进展[J].湖南中医药大学学报,2021,41(3):472-478[点击复制] |
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| 重复经颅磁刺激干预中枢神经系统疾病的生物标志物研究进展 |
| 杨娅婕,赵宁,曹玉婷,王桂喜 |
| (深圳大学第六附属医院康复医学科, 广东 深圳 518052;华中科技大学协和深圳医院康复医学科, 广东 深圳 518052;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 生物标志物对于医学的合理发展至关重要，在科学研究与临床实践中具有重要意义。本文就近年来重复经颅磁刺激治疗中枢神经系统疾病研究中基于生物标志物分析的文献进行总结，发现治疗后中枢神经系统疾病患者的行为学改变与生物标志物的改变呈特定相关性，这些研究的报道可能为经颅磁治疗中枢神经系统疾病提供了更客观的代谢组学证据。 |
| 关键词: 重复经颅磁刺激 生物标记物 神经系统 可塑性 神经递质 氨基酸 炎症 细胞凋亡 |
| DOI：10.3969/j.issn.1674-070X.2021.03.028 |
| 投稿时间：2020-06-11 |
| 基金项目:国家自然科学基金面上项目（81874499）；广东省医学科研基金项目（A2018551）；深圳市南山区卫生科技项目（2019050）；深圳市南山区卫生科技项目（2018083）；华中科技大学协和深圳医院院内课题项目（2019004）。 |
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| Progress on Biomarkers of Repetitive Transcranial Magnetic Stimulation Intervention for Central Nervous System Diseases |
| YANG Yajie,ZHAO Ning,CAO Yuting,WANG Guixi |
| (Department of Rehabilitation Medicine, Sixth Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518052, China;Department of Rehabilitation Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong 518052, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Biomarkers are very important for the rational development of medicine, and have wide significance in scientific research and clinical practice. We summarized the literatures based on biomarker analysis in the study of repetitive transcranial magnetic stimulation in the treatment of central nervous system diseases in recent years, and found that the behavioral changes of patients with central nervous system diseases after treatment were specifically related to the changes of biomarkers. The reports of these studies may provide more objective metabonomics evidence for transcranial magnetic therapy of central nervous system diseases. |
| Key words: repetitive transcranial magnetic stimulation biomarkers nervous system plasticity neurotransmitters amino acids inflammation cell apoptosis |
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