| 引用本文: |
魏露,朱明芳.桉叶油抗金黄地鼠皮脂腺斑增生的研究[J].湖南中医药大学学报,2021,41(3):355-358[点击复制] |
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| 桉叶油抗金黄地鼠皮脂腺斑增生的研究 |
| 魏露,朱明芳 |
| (湖南中医药大学第二附属医院, 湖南 长沙 410005) |
| 摘要: |
| 目的 观察桉叶油对金黄地鼠皮脂腺斑的影响，探讨外用桉叶油乳膏治疗痤疮的机制。方法 将24只雄性金黄地鼠随机分为空白组、基质组、桉叶油乳膏组、阳性对照组，每组6只，分别于双侧皮脂腺斑处涂抹蒸馏水、基质、桉叶油乳膏、0.025%维A酸乳膏，连续给药4周后，观察各组金黄地鼠皮脂腺斑面积变化及组织病理学改变。结果 给药后，与空白组、基质组相比，各治疗组金黄地鼠同侧皮脂腺斑面积均减小，差异有统计学意义（P<0.05），同时皮脂腺厚度减少，腺体萎缩，腺叶数量减少，排列疏松；与阳性对照组相比，桉油乳膏组右侧皮脂腺斑的面积缩小，差异有统计学意义（P<0.05），同时皮脂腺腺体较小，排列松散。结论 桉叶油能有效抑制皮脂腺增生，可能是其治疗痤疮的作用机制之一。 |
| 关键词: 皮脂腺斑 痤疮 桉叶油 金黄地鼠 |
| DOI：10.3969/j.issn.1674-070X.2021.03.006 |
| 投稿时间：2020-08-14 |
| 基金项目:湖南省自然科学基金项目（2208）；湖南省卫生健康委2020年度科研计划项目（20201862）；长沙市科技局项目（kp1901097）；湖南省教育厅科学研究项目（18A212）；湖南省研究生科研创新项目（CX20190548）；湖南省高层次卫生人才“225”工程培养项目。 |
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| Study on Effect of Eucalyptus Oil on Proliferation of Sebaceous Gland Spots in Golden Hamsters |
| WEI Lu,ZHU Mingfang |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China) |
| Abstract: |
| Objective To observe the effect of eucalyptus oil on sebaceous gland spots in golden hamsters, and explore the mechanism of external use of eucalyptus oil cream in the treatment of acne. Methods 24 male golden hamsters were randomly divided into blank group, matrix group, eucalyptus oil cream group and positive control group, with 6 rats in each group. Distilled water, matrix, eucalyptus oil cream and 0.025% vitamin A cream were applied to bilateral sebaceous gland spots. After continuous treatment for 4 weeks, the change of sebaceous gland spots area of golden hamster in each group and histopathological changes were observed. Results After administration, compared with blank group and matrix group, the ipsilateral sebaceous plaque area of golden hamsters in each treatment group decreased, and the difference was statistically significant (P<0.05). At the same time, the thickness of sebaceous gland spots decreased, the gland atrophic, the number of glandular leaves decreased, and the arrangement was loose. Compared with the positive control group, the area of sebaceous spots on the right side of the eucalyptus oil cream group was reduced, and the difference was statistically significant (P<0.05). Meanwhile, the sebaceous gland spots were small and loosely arranged. Conclusion Eucalyptus oil can effectively inhibit sebaceous gland spots hyperplasia, which may be one of the mechanisms of acne treatment. |
| Key words: eucalyptus oil acne golden hamsters sebaceous gland spots |
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