| 引用本文: |
曹闲雅,匡浩铭,苏翔,谭学松,戎宽,匡建军.恒古骨伤愈合剂治疗腰椎间盘突出症肾虚血瘀证的临床研究[J].湖南中医药大学学报,2020,40(12):1548-1552[点击复制] |
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| 恒古骨伤愈合剂治疗腰椎间盘突出症肾虚血瘀证的临床研究 |
| 曹闲雅,匡浩铭,苏翔,谭学松,戎宽,匡建军 |
| (湖南中医药大学, 湖南 长沙 410208;湖南省中医药研究院附属医院, 湖南 长沙 410006;湖南省中医药研究院, 湖南 长沙 410006) |
| 摘要: |
| 目的 观察恒古骨伤愈合剂治疗腰椎间盘突出症肾虚血瘀证患者的临床疗效。方法 选取2019年1月至2020年1月在湖南省中医药研究院附属医院门诊就诊的腰椎间盘突出症肾虚血瘀证患者86例，采用随机数字表法将其分为观察组、对照组，各43例。对照组给予塞来昔布胶囊，辅以腰背肌锻炼治疗，观察组在此基础上应用恒古骨伤愈合剂。观察两组患者临床疗效及治疗前后视觉模拟评分法（visual analogue scale，VAS）评分、36项健康调查简表（short form health survey-36，SF-36）评分、血清肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）和白介素-1β（interleukin-1β，IL-1β）变化。结果 观察组总有效率90.70%，高于对照组79.07%（P<0.05）；观察组治疗后VAS评分、炎症细胞因子TNF-α和IL-1β水平低于对照组（P<0.05）；观察组治疗后SF-36评分均高于对照组（P<0.05）。结论 在腰椎间盘突出症肾虚血瘀证患者的非手术治疗中，恒古骨伤愈合剂联合塞来昔布胶囊，同时辅以腰背肌锻炼可有效提高患者的临床疗效、生活质量，降低相关炎性细胞因子水平。 |
| 关键词: 腰椎间盘突出症 肾虚血瘀证 恒古骨伤愈合剂 腰背肌锻炼 塞来昔布胶囊 |
| DOI：10.3969/j.issn.1674-070X.2020.12.021 |
| 投稿时间：2020-10-11 |
| 基金项目:国家中医药管理局全国名老中医药专家传承工作室建设项目；湖南省自然科学基金项目（2019JJ40173）；湖南省教育厅重点项目（18A221）。 |
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| Clinical Study on Osteoking for Lumbar Intervertebral Disc Herniation with Kidney Deficiency and Blood Stasis Syndrome |
| CAO Xianya,KUANG Haoming,SU Xiang,TAN Xuesong,RONG Kuan,KUANG Jianjun |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China) |
| Abstract: |
| Objective To evaluate the clinical efficacy by observing Osteoking in the treatment of patients with lumbar disc herniation of kidney deficiency and blood stasis syndrome. Methods A total of 86 patients with lumbar disc herniation of kidney deficiency and blood stasis syndrome were selected and randomly assigned into an observation group and a control group, with 43 cases in each group. The control group was given celecoxib capsule, supplemented by lumbar and dorsal muscle exercise therapy, and the observation group was given Osteoking on this basis. The clinical efficacy, visual analogue scale (VAS) score, short form health survey-36 (SF-36) score, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were compared and observed between the 2 groups. Results The total effective rate of the observation group was 90.70%, higher than 79.07% of the control group; the VAS score, inflammatory cytokines TNF-α and IL-1β in the observation group were lower than those in the control group (P<0.05); the SF-36 score of the observation group after treatment was higher than that of the control group (P<0.05). Conclusion In the non-surgical treatment of patients with kidney deficiency and blood stasis syndrome of lumbar disc herniation, Osteoking combined with celecoxib capsule, supplemented by lumbodorsal muscle exercise can effectively improve the clinical efficacy, quality of life, and reduce related inflammatory cytokine. |
| Key words: lumbar intervertebral disc herniation kidney deficiency and blood stasis syndrome Osteoking lumbodorsal muscle exercise celecoxib capsule clinical study |
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