| 引用本文: |
邓子宁,赵霞霞,祝美珍.清脑益元汤对缺血性中风急性期患者血清bFGF、PDGF、血浆Hcy、神经功能及日常生活能力的影响[J].湖南中医药大学学报,2020,40(11):1405-1408[点击复制] |
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| 清脑益元汤对缺血性中风急性期患者血清bFGF、PDGF、血浆Hcy、神经功能及日常生活能力的影响 |
| 邓子宁,赵霞霞,祝美珍 |
| (遵义市中医院, 贵州 遵义 563000;广西中医药大学, 广西 南宁 530001) |
| 摘要: |
| 目的 探讨清脑益元汤在治疗缺血性中风（cerebral ischemic stroke，CIS）急性期患者中对生长因子、炎症损伤修复、神经功能及日常生活能力的影响。方法 将60例CIS急性期患者分为清脑益元汤组（观察组）和常规治疗组（对照组），每组30例。对照组入院后给予常规治疗，观察组在对照组常规治疗基础上加用清脑益元汤，共治疗14 d。观察治疗前后两组患者血浆同型半胱氨酸（homocysteine，Hcy）、血清碱性成纤维细胞生长因子（basic fibroblast growth factor，bFGF）及血小板源性生长因子（platelet-derived growth factor，PDGF）的变化，治疗前后对两组患者的神经功能（NIHSS评分）和日常生活能力（Barthel指数评分）进行评定比较。结果 治疗后，两组患者血浆Hcy浓度均较治疗前下降，且观察组低于对照组（P<0.05）；治疗后，两组患者血清bFGF、PDGF浓度均较治疗前升高，且观察组高于对照组（P<0.05）；治疗后，两组患者NIHSS评分均较治疗前下降，Barthel指数评分均较治疗前升高，且观察组NIHSS评分低于对照组、Barthel指数评分高于对照组，差异均有统计学意义（P<0.05）。结论 清脑益元汤可能有促进CIS急性期患者炎症损伤修复、抑制神经细胞凋亡及促进血管内皮新生的作用，能有效改善患者的神经功能和日常生活能力，值得临床推广应用。 |
| 关键词: 缺血性中风 急性期 清脑益元汤 同型半胱氨酸 碱性成纤维细胞生长因子 血小板源性生长因子 NIHSS Barthel指数 |
| DOI：10.3969/j.issn.1674-070X.2020.11.021 |
| 投稿时间：2020-07-24 |
| 基金项目:国家自然科学基金项目（81460725）；贵州省中药管理局科研项目（QZYY2017-054）。 |
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| Effects of Qingnao Yiyuan Decoction on Serum bFGF, PDGF, Plasma Hcy, Nerve Function and Activities of Daily Living in Patients with Acute Ischemic Stroke |
| DENG Zining,ZHAO Xiaxia,ZHU Meizhen |
| (Zunyi Hospital of Traditional Chinese Medicine, Zunyi, Guizhou 563000, China;Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China) |
| Abstract: |
| Objective To investigate the effects of Qingnao Yiyuan Decoction on growth factor, inflammatory damage repair, nerve function and activities of daily living in patients with ischemic cerebrovascular disease (ICD). Methods A total of 60 patients with acute ICD who met the diagnostic criteria were divided into a Qingnao Yiyuan Decoction group (observation group) and a conventional treatment group (control group), with 30 cases in each group. The control group was given conventional treatment after admission, and the observation group was given Qingnao Yiyuan Decoction on the basis of conventional treatment in the control group, for a total of 14 days. The changes of plasma homocysteine (Hcy), serum basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in the 2 groups before and after treatment were observed. Before and after treatment, the neurological function (NIHSS score) and activities of daily living (Barthel index score) were determined and compared between the 2 groups. Results After treatment, the plasma Hcy concentration of the 2 groups decreased compared with that before treatment, and the observation group was lower than the control group (P<0.05); After treatment, the serum bFGF and PDGF concentrations of the 2 groups were increased than those before treatment, and the observation group was higher than the control group (P<0.05); after treatment, the NIHSS scores of the 2 groups were decreased, and the Barthel index score was increased than that before treatment. The NIHSS score of the observation group was lower than that of the control group, and the score of Barthel index was higher than that of control group. The differences were both statistically significant (P<0.05). Conclusion Qingnao Yiyuan Decoction may promote the repair of inflammatory injury, inhibit the apoptosis of nerve cells and promote the neovascularization of vascular endothelium in patients with ICD. It can effectively improve the neurological function and activities of daily living of patients, which is worthy of clinical application. |
| Key words: ischemic stroke acute phase Qingnao Yiyuan Decoction homocysteine basic fibroblast growth factor platelet-derived growth factor NIHSS Barthel index |
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